SYNTHETIC ANGUCYCLINS .2. FIRST TOTAL SYNTHESIS OF (+/-)-RABELOMYCIN
SYNTHETIC ANGUCYCLINS .2. FIRST TOTAL SYNTHESIS OF (+/-)-RABELOMYCIN
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DOI：
10.1002/anie.199400991
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发表时间：
1994-01-17
期刊：
影响因子：
--
通讯作者：
KHANBABAEE, K
中科院分区：
文献类型：
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作者：
KROHN, K;KHANBABAEE, K
为了保持不稳定羟基的位置并指导区域选择性去质子化，在二烯组分3中引入了Si 2 me5基团，通过环加成和随后的光氧化作用可以获得抗生素雷贝霉素(4)。本方法强调了由二硅烷1容易制备的五甲基硅基锂2用于合成叔醇的有用性。
To hold the position for a labile hydroxyl group and to direct a regioselective deprotonation, the Si 2 Me 5 group is introduced in the diene component 3, from which the antibiotic rac‐rabelomycin (4) is accessible through cycloaddition and subsequent photooxygenation. This procedure emphasizes the usefulness of the pentamethylsilyllithium 2, readily prepared from disilane 1, for the synthesis of tertiary alcohols.