Functional-anatomical validation and individual variation of diffusion tractography-based segmentation of the human thalamus
Functional-anatomical validation and individual variation of diffusion tractography-based segmentation of the human thalamus
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DOI：
10.1093/cercor/bhh105
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发表时间：
2005-01-01
期刊：
影响因子：
3.7
通讯作者：
Matthews, PM
中科院分区：
文献类型：
--
作者：
Johansen-Berg, H;Behrens, TEJ;Matthews, PM
基于从非侵入性扩散加权图像推断的皮质连接信息的人类丘脑的分割识别了我们提出的对应于核的子区域。在这里，我们通过比较弥散纤维束成像，细胞结构和功能成像的数据来测试这一建议的功能和解剖学有效性。我们采集了11名健康受试者的弥散成像数据，并从丘脑内的体素进行了概率纤维束成像。皮质连接信息用于将丘脑划分为与不同皮质区域连接概率最高的子区域。这些连通性定义的子区域的相对体积与基于组织学图谱的体积预测很好地相关。先前报道的运动或执行任务时丘脑内的功能激活中心在寰椎区域内共同定位，分别显示出与运动或前额叶皮质连接的高概率。这项工作提供了一个强大的验证定量灰质分割使用扩散纤维束成像在人类。共同注册的丘脑子区域从11个健康的个体之间的差异分割的特点，并在人群为基础的地图集的人类丘脑，可用于分配可能的解剖标签，以丘脑在标准的大脑空间的位置。这提供了一个工具，为特定的功能激活或病变定位到假定的丘脑核。
Parcellation of the human thalamus based on cortical connectivity information inferred from non-invasive diffusion-weighted images identifies sub-regions that we have proposed correspond to nuclei. Here we test the functional and anatomical validity of this proposal by comparing data from diffusion tractography, cytoarchitecture and functional imaging. We acquired diffusion imaging data in eleven healthy subjects and performed probabilistic tractography from voxels within the thalamus. Cortical connectivity information was used to divide the thalamus into sub-regions with highest probability of connectivity to distinct cortical areas. The relative volumes of these connectivity-defined sub-regions correlate well with volumetric predictions based on a histological atlas. Previously reported centres of functional activation within the thalamus during motor or executive tasks co-localize within atlas regions showing high probabilities of connection to motor or prefrontal cortices, respectively. This work provides a powerful validation of quantitative grey matter segmentation using diffusion tractography in humans. Co-registering thalamic sub-regions from 11 healthy individuals characterizes inter-individual variation in segmentation and results in a population-based atlas of the human thalamus that can be used to assign likely anatomical labels to thalamic locations in standard brain space. This provides a tool for specific localization of functional activations or lesions to putative thalamic nuclei.