Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine
Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine
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DOI：
10.1016/0024-3205(96)00498-5
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发表时间：
1996-10-04
期刊：
影响因子：
6.1
通讯作者：
Misawa, M
中科院分区：
文献类型：
--
作者：
Suzuki, T;Kishimoto, Y;Misawa, M
在大鼠后爪单侧注射2.5%福尔马林（50 μ l）和1%卡拉胶（100 μ l）后，观察吗啡、甲基苯丙胺和可卡因诱导的炎症下的位置偏好。福尔马林和卡拉胶降低了大鼠足跖压力阈值，痛感持续时间分别为9天和13 d。与非炎症组相比，吗啡、可卡因和甲基苯丙胺诱导的位置偏好在炎症组中显著减弱。然而，吲哚美辛在两组中都没有产生位置偏好。此外，随着炎症的愈合，吗啡诱导的位置偏好逐渐恢复到相应的对照组水平。这些结果表明，吗啡、可卡因和甲基苯丙胺的奖励作用在炎症伤害感觉存在时减弱。
Morphine-, methamphetamine- and cocaine-induced place preferences under inflammation produced by unilateral injections of 2.5 % formalin (50 mu l) and 1 % carrageenan (100 mu l) into the hind paw were examined in rats. Formalin and carrageenan reduced the paw pressure threshold, and this hyperalgesia lasted for 9 and 13 days, respectively. Morphine-, cocaine- and methamphetamine-induced place preferences were significantly attenuated in inflamed groups as compared with the respective noninflamed groups. However, indomethacin failed to produce a place preference in either group. Furthermore, the morphine-induced place preference in the inflamed group gradually recovered to the respective control level as the inflammation healed. These results suggest that the rewarding effects of morphine, cocaine and methamphetamine are attenuated in the presence of inflammatory nociception.