Once Daily Dosing Improves Adherence to Antiretroviral Therapy
Once Daily Dosing Improves Adherence to Antiretroviral Therapy
复制标题
每日一次给药可提高抗逆转录病毒治疗的依从性
作者：
J. Raboud;M. Li;S. Walmsley;C. Cooper;S. Blitz;A. Bayoumi;S. Rourke;S. Rueda;A. Rachlis;N. Mittmann;M. Smieja;E. Collins;M. Loutfy
我们在安大略队列研究的参与者中研究了每日一次给药与自我报告依从性的关系，这些参与者目前正在接受抗逆转录病毒治疗，并完成了一份90分钟的访谈问卷。次优依从性定义为在访谈前4天缺少≥1剂ART治疗。参与者（n = 779） 85%为男性，69%为男男性行为者，67%为白人，中位年龄48岁（IQR 42-54），中位ART治疗年数9 (IQR 5-13)，中位CD4计数463细胞/mm3 （IQR 320-638）。15%的参与者在访谈前4天报告了不理想的依从性。在多变量logistic回归模型中，在访谈前4天内，每天服用一次药物的参与者错过一次剂量的可能性减少了一半。非最佳依从性的其他独立相关因素是年龄较小，积极的社会互动较低，一次饮用160杯酒精饮料的频率增加。
We studied the association of once-daily dosing with self-reported adherence among participants of the Ontario Cohort Study who were currently taking ART and who had completed a 90-min interviewer-administered questionnaire. Suboptimal adherence was defined as missing ≥1 dose of ART in the 4 days prior to the interview. Participants (n = 779) were 85% male, 69% men having sex with men, 67% white, median age 48 years (IQR 42–54), median years of ART 9 (IQR 5–13) and median CD4 count 463 cells/mm3 (IQR 320–638). Fifteen percent of participants reported suboptimal adherence in the 4 days prior to the interview. In a multivariable logistic regression model, participants on once daily regimens were half as likely to miss a dose during the 4 days prior to the interview. Other independent correlates of suboptimal adherence were younger age, lower positive social interaction and increased frequency of consuming > 6 alcoholic drinks on one occasion.
影响因子：
5.9
作者：
Tucker, JS;Burnam, MA;Gifford, AL
通讯作者：
Gifford, AL
影响因子：
7.2
作者：
Justice, AC;Holmes, W;Wu, AW
通讯作者：
Wu, AW