AUDITORY-NERVE OF THE NORMAL AND JAUNDICED RAT .1. SPONTANEOUS DISCHARGE RATE AND COCHLEAR NERVE HISTOLOGY
AUDITORY-NERVE OF THE NORMAL AND JAUNDICED RAT .1. SPONTANEOUS DISCHARGE RATE AND COCHLEAR NERVE HISTOLOGY
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DOI：
10.1016/0378-5955(91)90138-y
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发表时间：
1991-07-01
期刊：
影响因子：
2.8
通讯作者：
ELBARBARY, A
中科院分区：
文献类型：
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作者：
ELBARBARY, A
高胆红素血症是新生儿重症监护的主要问题。听力障碍是其后遗症之一。虽然已知中枢听觉通路的损伤与人类和纯合子Gunn大鼠的这种疾病有关，但耳蜗病理学的存在仍然存在争议。本研究的目的是检测Gunn大鼠外周听觉系统的功能完整性。Gunn大鼠是Wistar品系的突变种，患有先天性的肝酶尿苷二磷葡萄糖醛酸基转移酶缺陷，尿苷二磷酸葡萄糖醛酸基转移酶是胆红素结合必不可少的。这种缺陷是一种常染色体隐性遗传特征，纯合动物(JJ)表现出胆红素脑病的证据。杂合子(JJ)有50%的酶缺乏症，没有黄褐症。Long-Evans大鼠作为对照。该方法是在封闭和校准的音响系统中使用标准程序研究单个听神经纤维的放电特性。分析了各种反应测量，这些测量将揭示耳蜗内的病理过程。在本研究中，Gunn大鼠听神经记录的自发放电率分布和棘波间期统计数据均在正常范围内，耳蜗神经组织学未发现神经病变的证据。
Hyperbilirubinemia is a major problem in neonatal intensive care. Hearing impairment is one of its sequelae. Although lesions of the central auditory pathways are known to be associated with this disorder in both humans and homozygous Gunn rats, the presence of cochlear pathology is still controversial. The purpose of this study was to examine the functional integrity of the peripheral auditory system in the Gunn rat. The Gunn rat is a mutant of the Wistar strain with congenital deficiency of the liver enzyme uridine diphosphoglucuronyl transferase which is essential for bilirubin conjugation. This deficiency is inherited as an autosomal recessive trait, with the homozygous animals (jj) showing evidence of bilirubin encephalopathy. The heterozygotes (Jj) have 50% enzyme deficiency and are not jaundiced. The Long-Evans rat served as a control. The approach was to study the discharge characteristics of single auditory nerve fibers using standard procedures in a closed and calibrated sound system. Various response measurements which would reveal pathological processes in the cochlea were analyzed. In this study, spontaneous discharge rate distribution and interspike interval statistics derived from Gunn rat auditory nerve recording were found to be within the normal range, and cochlear nerve histology showed no evidence of neuropathy.