Effects of a meal and bisacodyl on colonic motility in healthy volunteers and patients with slow-transit constipation
Effects of a meal and bisacodyl on colonic motility in healthy volunteers and patients with slow-transit constipation
复制标题
DOI：
10.1023/a:1024178303076
复制
发表时间：
2003-07-01
影响因子：
3.1
通讯作者：
Smout, AIPM
中科院分区：
文献类型：
--
作者：
De Schryver, AMP;Samsom, M;Smout, AIPM
在本研究中，在10名健康志愿者和10名慢传输型便秘患者（通过标记物研究确定）中研究了摄入标准化液体餐后的胃结肠反应和对局部化学刺激的反应。使用12通道水灌注导管记录空腹、进食标准餐和结肠内输注比沙可啶后的结肠压力。视觉识别传播超过至少20 cm（HAPPW）的压力波，并对剩余节段性运动进行自动分析。在健康受试者中观察到餐后和比沙可啶的运动性增加，而患者未显示出这些反应。比沙可啶输注后至发生首次HAPPW的时间倾向于延长（4.3 +/- 1.4 vs 36.1 +/- 15.3; P = 0.053），输注后前30分钟内的HAPPW数量低于健康受试者（2.1 +/- 0.2 vs 5.4 +/- 0.3; P < 0.01）。在便秘患者中，出现冲动或痉挛的HAPPWs百分比显著较低（53 +/- 3% vs 95 +/- 1%; P < 0.005）。总之，本研究表明，在慢传输型便秘患者中，对进餐和比沙可啶的结肠运动反应以及比沙可啶诱导的传播压力波感知降低。
In the present study, the gastrocolonic response after ingestion of a standardized liquid meal and the response to a local chemical stimulus were investigated in 10 healthy volunteers and 10 patients with slow-transit constipation ( as determined by marker studies). Colonic pressures were recorded while fasting, after ingestion of a standardized meal and after intracolonic bisacodyl infusion, using a 12-channel water-perfused catheter. Pressure waves propagating over at least 20 cm (HAPPW) were identified visually and automated analysis was carried out on remaining segmental motility. Increases of motility after a meal and bisacodyl were seen in healthy subjects, whereas patients did not show these responses. The time until occurrence of the first HAPPW after bisacodyl infusion tended to be prolonged (4.3 +/- 1.4 vs 36.1 +/- 15.3; P = 0.053) and the number of HAPPWs in the first 30 min. after infusion was lower compared to healthy subjects (2.1 +/- 0.2 vs 5.4 +/- 0.3; P < 0.01). The percentage of HAPPWs that were experienced as urge or cramp was significantly lower in constipated patients (53 +/- 3% vs 95 +/- 1%; P < 0.005). In conclusion, this study shows that in patients with slow-transit constipation, the colonic motor response to a meal and to bisacodyl, as well as the perception of bisacodyl-induced propagated pressure waves is decreased.