Liquid Biopsy in Endometrial Cancer: New Opportunities for Personalized Oncology.
Liquid Biopsy in Endometrial Cancer: New Opportunities for Personalized Oncology.
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DOI：
10.3390/ijms19082311
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发表时间：
2018-08-07
影响因子：
5.6
通讯作者：
Abal M
中科院分区：
文献类型：
--
作者：
Muinelo-Romay L;Casas-Arozamena C;Abal M
与高复发风险和治疗反应相关的新分子靶点和生物标志物的鉴定是子宫内膜癌晚期疾病管理的主要临床挑战之一。从这个意义上说，液体活检领域已经成为肿瘤学的一场伟大革命，被认为是实现个性化医疗的“途径”。在这篇综述中，我们讨论了与乳腺癌、结直肠癌或前列腺癌等其他类型的肿瘤相比，子宫内膜癌液体活检的前景光明但已经相对有限的进展。我们提供了最新的数据，分析了微创血液样本中的循环肿瘤物质，也分析了子宫抽吸物等替代形式的液体活检中的循环肿瘤物质。专注于液体子宫样本的蛋白质组学和基因组研究不仅产生了最佳的诊断工具，而且产生了解决肿瘤异质性的可靠方法。同样，循环肿瘤细胞 (CTC) 和循环肿瘤 DNA (ctDNA) 为对患者进行正确分层、评估早期复发性疾病或实时监测治疗反应提供了机会。适当设计的研究和临床试验的实施将确定液体活检在子宫内膜癌精准肿瘤学中的价值。
The identification of new molecular targets and biomarkers associated with high risk of recurrence and response to therapy represents one of the main clinical challenges in the management of advanced disease in endometrial cancer. In this sense, the field of liquid biopsy has emerged as a great revolution in oncology and is considered “the way” to reach personalised medicine. In this review, we discuss the promising but already relatively limited advances of liquid biopsy in endometrial cancer compared to other types of tumours like breast, colorectal or prostate cancer. We present recent data analysing circulating tumour material in minimally-invasive blood samples, but also in alternative forms of liquid biopsy like uterine aspirates. Proteomic and genomic studies focused on liquid-based uterine samples are resulting not only in optimal diagnostic tools but also in reliable approaches to address tumour heterogeneity. Likewise, circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA) represent an opportunity for the correct stratification of patients, for the assessment of early recurrent disease or for the real-time monitoring of therapy responses. Appropriately designed studies and implementation in clinical trials will determine the value of liquid biopsy for precision oncology in endometrial cancer.
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