A study on the interaction between ibuprofen and bilayer lipid membrane
A study on the interaction between ibuprofen and bilayer lipid membrane
复制标题
布洛芬与双层脂膜相互作用的研究
DOI：
10.1016/j.electacta.2006.03.009
复制
发表时间：
2006-08-15
影响因子：
6.6
通讯作者：
Wang, Erkang
中科院分区：
文献类型：
--
作者：
Du, Liangwei;Liu, Xiaohua;Wang, Erkang
布洛芬是一种众所周知的非甾体抗炎药，它可以与脂质膜相互作用。采用紫外-可见光谱、循环伏安法和交流阻抗法研究了布洛芬与双层脂质膜的相互作用。紫外可见光谱数据直接表明布洛芬可以与脂质囊泡相互作用。在电化学实验中，布洛芬在玻璃碳电极支撑的双层脂膜上表现出双相行为。在低浓度下，它可以稳定脂膜，但随着浓度的增加，它会引起缺陷的形成，甚至会使电极表面的双层脂膜脱落。探讨了布洛芬与支撑双层脂膜相互作用的机理。(c) 2006年Elsevier Ltd出版
Ibuprofen is a well-known nonsteroidal anti-inflammatory drug, which can interact with lipid membranes. In this paper, the interaction of ibuprofen with bilayer lipid membrane was studied by UV-vis spectroscopy, cyclic voltammetry and AC impedance spectroscopy. UV-vis spectroscopy data indicated directly that ibuprofen could interact with lipid vesicles. In electrochemical experiments, ibuprofen displayed a biphasic behavior on bilayer lipid membrane supported on a glassy carbon electrode. It could stabilize the lipid membrane in low concentration, while it induced defects formation, even removed off bilayer lipid membrane from the surface of the electrode with increasing concentration. The mechanism about the interaction between ibuprofen and supported bilayer lipid membrane was discussed. (c) 2006 Published by Elsevier Ltd.