Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biology.
Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biology.
复制标题
DOI：
--
复制
发表时间：
2011
影响因子：
--
通讯作者：
Tamisha Y. Vaughan;S. Verma;K. Bunting
中科院分区：
文献类型：
--
作者：
Tamisha Y. Vaughan;S. Verma;K. Bunting
Grb 2相关结合（Gab）支架/衔接蛋白是一个由三个成员组成的家族，包括哺乳动物中高度保守的Gab 1、Gab 2和Gab 3。自从发现这些蛋白质以来，已经做了大量的工作来更好地理解Gab在多个信号通路中的功能作用，通常作为受体酪氨酸激酶（RTK）触发的信号转导的下游效应物。除了参与造血外，Gabs还在免疫反应的调节和癌细胞信号传导中发挥重要作用。Gabs可能发挥复杂的作用，因此对它们的相互作用以及它们如何调节造血和免疫细胞生物学的完整理解仍有待确定。这篇综述将涵盖最新的研究结果，包括Gabs参与疾病发展和信号传导，这对未来治疗干预措施的设计至关重要。
Grb2-associated binding (Gab) scaffolding/adapter proteins are a family of three members including mammalian Gab1, Gab2, and Gab3 that are highly conserved. Since the discovery of these proteins, there has been an extensive amount of work done to better understand Gab functional roles in multiple signaling pathways, typically acting as a downstream effectors of receptor-tyrosine kinase (RTK)-triggered signal transduction. In addition to their participation in hematopoiesis, Gabs play important roles in regulation of immune response and in also in cancer cell signaling. Gabs may play complex roles and thus a complete understanding of their interactions and how they modulate hematopoietic and immune cell biology remains to be determined. This review will cover the most recent findings including the involvement of Gabs in disease development and signaling which will be important for design of future therapeutic interventions.