The secret message of heterochromatin: new insights into the mechanisms and function of centromeric and pericentric repeat sequence transcription
The secret message of heterochromatin: new insights into the mechanisms and function of centromeric and pericentric repeat sequence transcription
复制标题
DOI：
10.1387/ijdb.082673ae
复制
发表时间：
2009-01-01
影响因子：
0.7
通讯作者：
Vourc'h, Claire
中科院分区：
文献类型：
--
作者：
Eymery, Angeline;Callanan, Mary;Vourc'h, Claire
在裂殖酵母中，S. Pombe，由RNAi依赖机制产生的小dsRNA参与异染色质区域的建立和维持。在酵母、小鼠和人类中，着丝粒和近着丝粒重复序列的一般组织内存在保守特征，这支持这些物种中着丝粒和近着丝粒衍生的转录物的保守作用。在支持这一点，越来越多的证据表明，着丝粒和近着丝粒序列在哺乳动物细胞的不同生物学背景下是转录能力。鉴于着丝粒和近着丝粒区域的重要性，不仅相对于着丝粒的功能，而且基因调控，本文综述了生物学背景下，小鼠和人类的着丝粒和近着丝粒特异性转录已被观察到。将讨论所产生的转录本的结构、其表达的分子机制及其假定的功能。
In the fission yeast, S. Pombe, small dsRNA generated by RNAi-dependent mechanisms are involved in the establishment and maintenance of heterochromatic regions. The existence of conserved features within the general organization of centromeric and pericentromeric repeats in yeast, mouse and human argues in favor of a conserved role for centromeric and pericentromeric-derived transcripts across these species. In support of this, evidence is accumulating that centromeric and pericentromeric sequences are transcriptionally competent in diverse biological contexts in mammalian cells. Given the importance of centromeric and pericentromeric regions, not only with respect to centromere function, but also to gene regulation, this review examines the biological contexts in which mouse and human centromeric and pericentromeric specific transcripts have been observed. The structure of the transcripts generated, the molecular mechanisms underlying their expression and their supposed functions will be discussed.