Gold-Nanoparticle-Assisted Plasmonic Photothermal Therapy Advances Toward Clinical Application
Gold-Nanoparticle-Assisted Plasmonic Photothermal Therapy Advances Toward Clinical Application
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DOI：
10.1021/acs.jpcc.9b01961
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发表时间：
2019-06-27
影响因子：
3.7
通讯作者：
El-Sayed, Mostafa A.
中科院分区：
文献类型：
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作者：
Ali, Moustafa R. K.;Wu, Yue;El-Sayed, Mostafa A.
等离子体光热疗法(PPTT)是一种通过静脉或肿瘤内注射将金纳米颗粒引入癌细胞，然后暴露在产生热的近红外光下的治疗方法，是一种潜在的替代局部肿瘤的传统治疗方法，如化疗、放射治疗和手术。然而，目前PPTT的主要关注点是该疗法在临床环境中的可行性。自从15年前PPTT首次使用以来，已经发表了数千项研究。在这篇专题文章中，我们综述了PPTT的最新科学进展，包括PPTT在体外和体内对癌细胞的作用、分子机制、毒性和药代动力学，通过小鼠/大鼠模型试验、动物临床病例(如狗和猫)和人类临床试验。鉴于PPTT的好处，我们相信它最终将成为一种人类临床治疗方法，有助于我们战胜癌症的最终目标。
Plasmonic photothermal therapy (PPTT), a type of treatment involving the intravenous or intratumoral injection to introduce gold nanoparticles to cancerous cells and the subsequent exposure to heat generating near-infrared (NIR) light, is a potentially favorable alternative to traditional treatments of localized tumors such as chemotherapy, radiotherapy, and surgery. The current main concern of PPTT, however, is the feasibility of the treatment in clinical settings. Since PPTT's initial use 15 years ago, thousands of studies have been published. In this feature article, we summarize the most recent scientific progress, including the efficacy, molecular mechanism, toxicity, and pharmacokinetics of PPTT in vitro with cancer cells and in vivo through mouse/rat model testing, animal clinical cases (such as dogs and cats), and human clinical trials. Given the benefits of PPTT, we believe that it will ultimately become a human clinical treatment that can aid in our ultimate goal of beating cancer.