FGF signaling in skeletal development.
FGF signaling in skeletal development.
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DOI：
10.1080/15513819809168795
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发表时间：
1998-07
期刊：
影响因子：
--
通讯作者：
M. Naski;D. Ornitz
中科院分区：
文献类型：
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作者：
M. Naski;D. Ornitz
成纤维细胞生长因子受体家族由四个受体酪氨酸激酶组成，它们与至少15个多肽配体家族具有不同的亲和力和特异性。受体和配体在生长、发育和修复过程中发挥许多重要功能。最近的发现表明，越来越多的骨骼异常是由于成纤维细胞生长因子受体的突变造成的。这些发现使人们更好地了解成纤维细胞生长因子信号在骨骼形成过程中的作用，并将研究重点放在成纤维细胞生长因子对软骨内和膜内骨发育的影响上。
The fibroblast growth factor receptor family consists of four receptor tyrosine kinases which bind with varying affinity and specificity to a family of at least fifteen polypeptide ligands. The receptors and ligands perform many essential functions during growth, development and repair. Recent discoveries show that a growing number of skeletal abnormalities result from mutations in the fibroblast growth factor receptors. These findings have led to a greater understanding of the role of fibroblast growth factor signaling during skeletogenesis and have focused research interests on the effects of fibroblast growth factors on endochondral and intramembranous bone development.