Progranulin: a novel regulator of gastrointestinal cancer progression.
Progranulin: a novel regulator of gastrointestinal cancer progression.
复制标题
促生蛋白：胃肠癌进展的新型调节剂。
DOI：
10.3978/j.issn.2224-4778.2013.02.02
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Demorrow S
中科院分区：
文献类型：
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作者：
Demorrow S
原颗粒蛋白(PGRN)是一种调节细胞增殖、运动和炎症的可溶性因子。PGRN在卵巢癌和乳腺癌进展中的作用已经得到了很好的证实。然而，PGRN在胃肠道肿瘤进展中的表达和后续后果还没有得到很好的认识。本文简要总结了目前对PGRN作用机制的认识，并着重介绍了该信号分子在多种胃肠道肿瘤中的作用。
Progranulin (PGRN) is a soluble factor that regulates cell proliferation, motility and inflammation. A role for PGRN in the progression of ovarian and breast cancers is well established. However, the expression and subsequent consequences of PGRN on the progression of gastrointestinal tumors is not well recognized. This review briefly summarizes our current knowledge of the mechanisms of action of PGRN and highlights the role of this signaling molecule in various gastrointestinal cancers.