4D physiologically adaptable cardiac patch: A 4-month in vivo study for the treatment of myocardial infarction
4D physiologically adaptable cardiac patch: A 4-month in vivo study for the treatment of myocardial infarction
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DOI：
10.1126/sciadv.abb5067
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发表时间：
2020-06-01
期刊：
影响因子：
13.6
通讯作者：
Zhang, Lijie Grace
中科院分区：
文献类型：
--
作者：
Cui, Haitao;Liu, Chengyu;Zhang, Lijie Grace
近年来，工程化心脏支架材料在心肌梗死治疗中的应用取得了长足的进展。然而，使用传统的生物工程方法复制心脏组织的结构特异性和可变性仍然具有挑战性。在这项研究中，一个四维（4D）心脏补片的生理适应性已打印光束扫描立体光刻。通过将独特的4D自变形能力与可扩展的微结构相结合，特定的设计已被证明可以改善贴片本身的生物力学特性以及贴片与跳动的心脏的动态整合。我们的研究结果表明，在生理相关的机械刺激下，体外血管形成和心肌细胞成熟得到改善，以及在小鼠慢性MI模型中细胞植入和血管供应增加。这项工作不仅潜在地为MI提供了有效的治疗方法，而且还为增强用于器官再生的复杂组织的结构设计提供了尖端方法。
There has been considerable progress in engineering cardiac scaffolds for the treatment of myocardial infarction (MI). However, it is still challenging to replicate the structural specificity and variability of cardiac tissues using traditional bioengineering approaches. In this study, a four-dimensional (4D) cardiac patch with physiological adaptability has been printed by beam-scanning stereolithography. By combining a unique 4D self-morphing capacity with expandable microstructure, the specific design has been shown to improve both the biomechanical properties of the patches themselves and the dynamic integration of the patch with the beating heart. Our results demonstrate improved vascularization and cardiomyocyte maturation in vitro under physiologically relevant mechanical stimulation, as well as increased cell engraftment and vascular supply in a murine chronic MI model. This work not only potentially provides an effective treatment method for MI but also contributes a cutting-edge methodology to enhance the structural design of complex tissues for organ regeneration.