Effects of number of cagemates on home cage ethanol drinking during proximal cagemate drinking (PCD) procedures in male and female CD-1 mice.
Effects of number of cagemates on home cage ethanol drinking during proximal cagemate drinking (PCD) procedures in male and female CD-1 mice.
复制标题
雄性和雌性 CD-1 小鼠近端笼友饮酒 (PCD) 过程中笼友数量对家笼乙醇饮用的影响。
DOI：
10.1016/j.pnpbp.2014.10.001
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发表时间：
2015
影响因子：
5.6
通讯作者：
Yu,Lei
中科院分区：
文献类型：
--
作者：
Tomie,Arthur;Samuel,AllisonGayle;Sprung,DanaMichelle;Malul,Yael;Yu,Lei
本实验评价了雄性和雌性CD-1小鼠近端笼饮水（PCD）程序期间笼舍数量（0 vs 1 vs 2）对饲养笼乙醇饮水的影响。采用连续进入饲养笼2瓶（乙醇vs.水）自由选择程序。PCD程序通过在饮酒者与其笼友之间施加半透明塑料屏障条，消除了饮酒者与其笼友之间直接身体接触对饮酒的分散注意力的影响。如果直接的身体接触分散了饮酒的注意力，那么一个Cagemate会比两个Cagemate在屏障的同一侧喝更多的乙醇和水。由于额外笼友的社会刺激效应，即使两个笼友在屏障另一侧的饮酒者中刺激更多的乙醇饮用，情况也是如此。结果表明，女性饮酒者的酒精摄入量与隔离带另一侧的笼仔数量直接相关，但在男性饮酒者中没有观察到这种社会刺激效应。对于雄性笼鼠和雌性笼鼠，相对于两笼鼠条件下每个笼鼠的乙醇摄入量和水摄入量，单笼鼠提供了升高的乙醇摄入量和升高的水摄入量。数据显示，笼友之间的直接身体接触减少了他们的乙醇摄入量，即使在刺激乙醇摄入量的饮酒者的另一边的障碍，这表明社会刺激对乙醇饮用的影响并不完全是由于建模或同伴压力的影响。PCD程序允许评价广泛的社会因素对小鼠饮用笼内乙醇的影响。
The present experiment evaluated the effects of the Number of Cagemates (0 vs 1 vs 2) on home cage ethanol drinking during Proximal Cagemate Drinking (PCD) procedures in Male and Female CD-1 mice. Continuous-access home cage 2-bottle (ethanol vs. water) free-choice procedures were employed. PCD procedures eliminate the distracting effects of direct physical contact between Drinkers and their Cagemates on ethanol drinking by imposing a translucent plastic barrier strip between them. If direct physical contact distracts from drinking, then one Cagemate would drink more ethanol and more water than two Cagemates housed together on the same side of the barrier. This would be the case even if two Cagemates stimulated more ethanol drinking in the Drinker housed on the other side of the barrier, due to the social stimulation effects of additional Cagemates. Results revealed that the ethanol intake of Female Drinkers was directly related to the number of Cagemates on the other side of the barrier strip, but this social stimulation effect was not observed in Male Drinkers. For Male Cagemates and Female Cagemates, the single Cagemate provided elevated ethanol intake and elevated water intake relative to the ethanol intake and water intake of each Cagemate in the two Cagemates condition. The data revealed that direct physical contact between Cagemates reduced their ethanol intake, even while stimulating ethanol intake of the Drinker on the other side of the barrier, indicating that the effects of social stimulation on ethanol drinking are not entirely due to effects of modeling or peer pressure. The PCD procedures allow the evaluation of effects of a broad range of social factors on home cage ethanol drinking in mice.