Tubule epithelial cells and fibroblasts communication: Vicious cycle of renal fibrosis.
Tubule epithelial cells and fibroblasts communication: Vicious cycle of renal fibrosis.
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DOI：
10.1016/j.ebiom.2022.104360
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发表时间：
2022-12
期刊：
影响因子：
11.1
通讯作者：
Lv, Lin-Li
中科院分区：
文献类型：
--
作者：
Shen, An-Ran;Lv, Lin-Li
慢性肾脏病（CKD）已被公认为全球主要的公共卫生负担，其原因是糖尿病、高血压、肥胖和老龄化的患病率不断增加，但有效的治疗选择有限。1肾脏纤维化是CKD的病理特征，无论其潜在原因如何。因此，更清楚地了解其机制对于确定CKD潜在的治疗靶点至关重要。肾小管上皮细胞是数量最多的细胞类型，易受各种损伤刺激的影响。近年来，肾小管损伤在肾纤维化过程中所传递的信号越来越受到人们的关注。单细胞RNA测序技术已经揭示了表达促炎和促纤维化细胞因子的适应不良或修复失败的近端小管簇的出现。2，3这些受损的肾小管分泌细胞因子，如CXCL 1，它与CXCR 2+嗜碱性粒细胞相互作用，促进肾纤维化的发展。4肾小管细胞发生自噬后释放FGF 2作为旁分泌因子，导致成纤维细胞活化和肾纤维化。5除了细胞因子外，肾小管还通过分泌细胞外囊泡与巨噬细胞或成纤维细胞沟通，细胞外囊泡携带功能性货物，如TGF-β1 mRNA、CCL 2 mRNA和骨桥蛋白。6-8因此
Chronic kidney disease (CKD) has been recognized as a leading public health burden worldwide driven by the increasing prevalence of diabetes mellitus, hypertension, obesity, and aging, but effective treatment options are limited. 1 Renal fibrosis is the pathological feature of CKD regardless of underlying causes. Therefore, a clearer understanding of the mechanism is essential for defining potential therapeutic target for CKD.Tubule epithelial cells are the most populous cell type which are vulnerable to a variety of injury stimuli. In recent years, the signals sending by injured tubules in the process of renal fibrosis has attracted increasing attention. Single-cell RNA-sequencing technologies have revealed the appearance of maladaptive or failed repaired proximal tubule clusters which express proinflammatory and profibrotic cytokines. 2, 3 Those injured tubules secrete cytokines, such as CXCL1 which interacts with CXCR2+ basophils, contributing to the development of renal fibrosis. 4 Tubular cells undergoing autophagy release FGF2 as paracrine factor leading to fibroblast activation and renal fibrosis. 5 In addition to cytokines, tubules also communicate with macrophages or fibroblast via secreting extracellular vesicles carrying functional cargoes such as TGF-β1 mRNA, CCL2 mRNA and Osteopontin protein. 6–8 Therefore, the
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DOI：
10.1097/01.asn.0000101180.96787.02
发表时间：
2003-12-01
影响因子：
13.6
作者：
Yoshino, J;Monkawa, T;Saruta, T
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Saruta, T
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影响因子：
11.1
作者：
Xu, Shihui;Yang, Xiaobing;Chen, Qingzhou;Liu, Zhuoliang;Chen, Ying;Yao, Xiaotian;Xiao, An;Tian, Jianwei;Xie, Liling;Zhou, Miaomiao;Hu, Zheng;Zhu, Fengxin;Xu, Xin;Hou, Fanfan;Nie, Jing
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Nie, Jing
影响因子：
13.6
作者：
Borges, Fernanda T.;Melo, Sonia A.;Kalluri, Raghu
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Kalluri, Raghu
DOI：
10.1073/pnas.2026684118
发表时间：
2021-07-06
影响因子：
11.1
作者：
Gerhardt LMS;Liu J;Koppitch K;Cippà PE;McMahon AP
通讯作者：
McMahon AP