Actions of Metformin in the Brain: A New Perspective of Metformin Treatments in Related Neurological Disorders.
Actions of Metformin in the Brain: A New Perspective of Metformin Treatments in Related Neurological Disorders.
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二甲双胍在大脑中的作用：二甲双胍治疗相关神经疾病的新视角
DOI：
10.3390/ijms23158281
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发表时间：
2022-07-27
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
二甲双胍是治疗2型糖尿病（T2 DM）的一线药物，也是世界上最常用的处方药之一。除了降糖作用外，二甲双胍还可改善部分T2 DM患者的认知或情绪功能;此外，据报道二甲双胍对许多神经系统疾病（包括重度抑郁症（MDD）、阿尔茨海默病（AD）和脆性X综合征（FXS））具有有益作用;然而，二甲双胍在大脑中的潜在机制尚未完全了解。神经元之间的神经传递是大脑功能的基础，它的缺陷与许多神经系统疾病有关。最近的研究表明，二甲双胍似乎不仅在病理条件下调节突触传递或可塑性，而且还调节神经网络中兴奋和抑制的平衡（E/I平衡）。在这篇综述中，我们关注并回顾了二甲双胍在脑功能和相关神经系统疾病中的作用，这将使我们更深入地了解二甲双胍在大脑中的作用。
Metformin is a first-line drug for treating type 2 diabetes mellitus (T2DM) and one of the most commonly prescribed drugs in the world. Besides its hypoglycemic effects, metformin also can improve cognitive or mood functions in some T2DM patients; moreover, it has been reported that metformin exerts beneficial effects on many neurological disorders, including major depressive disorder (MDD), Alzheimer’s disease (AD) and Fragile X syndrome (FXS); however, the mechanism underlying metformin in the brain is not fully understood. Neurotransmission between neurons is fundamental for brain functions, and its defects have been implicated in many neurological disorders. Recent studies suggest that metformin appears not only to regulate synaptic transmission or plasticity in pathological conditions but also to regulate the balance of excitation and inhibition (E/I balance) in neural networks. In this review, we focused on and reviewed the roles of metformin in brain functions and related neurological disorders, which would give us a deeper understanding of the actions of metformin in the brain.
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影响因子：
168.9
作者：
Ballard, Clive;Gauthier, Serge;Jones, Emma
通讯作者：
Jones, Emma
DOI：
10.3233/jad-180263
发表时间：
2018
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Campbell JM;Stephenson MD;de Courten B;Chapman I;Bellman SM;Aromataris E
通讯作者：
Aromataris E
DOI：
10.1002/mds.27128
发表时间：
2017-11
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Brakedal B;Flønes I;Reiter SF;Torkildsen Ø;Dölle C;Assmus J;Haugarvoll K;Tzoulis C
通讯作者：
Tzoulis C
影响因子：
3.1
作者：
Ahmed, Sara;Mahmood, Zahra;Zahid, Saadia
通讯作者：
Zahid, Saadia
影响因子：
5
作者：
Beckner, ME;Gobbel, GT;Pollack, IF
通讯作者：
Pollack, IF