Calix[4]pyrrole-calix[4]arene-crown-5 conjugate with flexible linkers as a model for a selective ion-pair container.
Calix[4]pyrrole-calix[4]arene-crown-5 conjugate with flexible linkers as a model for a selective ion-pair container.
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带有柔性接头的 Calix[4]pyrrole-calix[4]arene-crown-5 缀合物作为选择性离子对容器的模型。
DOI：
10.1002/asia.201100511
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Lee,Chang-Hee
中科院分区：
文献类型：
--
作者：
Park,In-Won;Kim,Sung-Kuk;Lee,Mee-Ja;Lynch,VincentM;Sessler,JonathanL;Lee,Chang-Hee
实现阳离子和阴离子客体（离子对或盐）与单一受体的同时识别和结合是超分子化学中公认的挑战。引发这种功能的系统在离子提取领域中是令人感兴趣的，作为这种关键生物功能（例如跨膜离子转运）的可能模拟物，以及作为分子传感器和逻辑门的识别元件。迄今为止，已经报道了在单个分子框架内含有两个不同结合位点的许多系统。[1-3]这些系统中的大多数具有空间上分离的异位结合域，例如用于阳离子络合的冠醚部分和用于阴离子结合的酰胺官能团。[4]例如，最近的一份报告详细介绍了硫脲基团和大环氧化膦的组合使用，以实现有效的离子对识别。[5]然而，现在已知的含有阴离子和阳离子识别基序的系统并不多。[4，6]基于该现有工作，现在至少作为一般规则，认识到最有效的离子对识别系统是其中使用适当预组织的框架来组织各个识别基序使得共结合的阴离子和阳离子驻留在其中的那些。
Achieving the simultaneous recognition and binding of cationic and anionic guests (ion pair or salts) with a single receptor is a recognized challenge in supramolecular chemistry. Systems that elicit such functions are of interest in the area of ion extraction, as possible mimics for such key biological functions such as transmembrane ion transport, and as recognition elements for molecular sensors and logic gates. To date, a number of systems containing two different binding sites within a single molecular framework have been reported.[1–3] Most of these systems possess spatially separated heterotopic binding domains, such as a crown ether moiety for cation complexation and an amide functionality for anion binding.[4] For example, a recent report detailed the combined use of a thiourea group and macrocyclic phosphine oxide for effective ion-pair recognition.[5] However, not many systems containing anion and cation recognition motifs are now known.[4, 6]On the basis of this prior work, it is now appreciated, at least as a general rule, that the most effective ion-pair recognition systems are those wherein a properly preorganized framework is used to organize the individual recognition motifs such that the co-bound anion and cation reside in