Renal synthesis, degradation and active transport of aliphatic acyl amino acids relationship to p-aminohippurate transport.
Renal synthesis, degradation and active transport of aliphatic acyl amino acids relationship to p-aminohippurate transport.
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脂肪族酰基氨基酸的肾脏合成、降解和主动转运与对氨基马尿酸转运的关系。
DOI：
10.1152/ajplegacy.1955.182.3.537
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发表时间：
1955
期刊：
影响因子：
--
通讯作者：
J. Taggart
中科院分区：
文献类型：
--
作者：
D. Schachter;J. Manis;J. Taggart
在体外和Z&O实验B中，各种代谢中间产物的低浓度对对氨基马尿酸(PAH)的肾小管排泄机制产生了深远的影响。在兔(I)、狗(2)和人(3)体内，醋酸盐及其前体乳酸和丙酮酸可使PAH的转运速度增加30%或更多。相反，低浓度的柠檬酸循环中的二元酸、中等碳链长度的脂肪酸(Ce-CIJ)和某些氨基酸，即Ce-CIj，都显著地抑制了PAH的转运。L-丙氨酸和L-谷氨酸(I)。不同底物对多环芳烃转运的增强或抑制似乎都与对细胞呼吸的影响没有直接关系。本实验室最近的研究涉及马尿酸和其他N-酰甘氨酸的生物合成(4，5)。辅酶A的酰基硫代酯(R-CO-S-CoA)是酰基甘氨酸合成中能量丰富的中间体，如下式所示：
OTH in vitro and in z&o experiments B have shown that low concentrations of various metabolic intermediates exert a profound influence on the mechanism responsible for the tubular excretion of p-aminohippurate (PAH). Acetate and its precursors, lactate and pyruvate, increase the rate of PAH transport by 30-IOO%, or more, in the rabbit (I), dog (2) and man (3). In contrast, PAH transport is depressed markedly by low concentrations of the dicarboxylic acids of the citric acid cycle, by fatty acids of intermediate carbon chain length (Ce-CIJ, and by certain amino acids, viz. L-alanine and L-glutamate (I). Neither the augmentation or depression of PAH transport by the various substrates appears to be related directly to effects on cellular respiration. Recent studies in this laboratory have been concerned with the biosynthesis of hippurate and other N-acylglycines (4, 5). The acyl thio esters of coenzyme A (R-CO-S-CoA) have been established as the energy-rich intermediates in acylglycine synthesis, as shown in the following equations: