Preclinical and clinical progress for HDAC as a putative target for epigenetic remodeling and functionality of immune cells.
Preclinical and clinical progress for HDAC as a putative target for epigenetic remodeling and functionality of immune cells.
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HDAC 作为免疫细胞表观遗传重塑和功能推定靶标的临床前和临床进展
DOI：
10.7150/ijbs.62001
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发表时间：
2021
影响因子：
9.2
通讯作者：
Zhao H
中科院分区：
文献类型：
--
作者：
Zhang S;Zhan L;Li X;Yang Z;Luo Y;Zhao H
Genetic changes are difficult to reverse; thus, epigenetic aberrations, including changes in DNA methylation, histone modifications, and noncoding RNAs, with potential reversibility, have attracted attention as pharmaceutical targets. The current paradigm is that histone deacetylases (HDACs) regulate gene expression via deacetylation of histone and nonhistone proteins or by forming corepressor complexes with transcription factors. The emergence of epigenetic tools related to HDACs can be used as diagnostic and therapeutic markers. HDAC inhibitors that block specific or a series of HDACs have proven to be a powerful therapeutic treatment for immune-related diseases. Here, we summarize the various roles of HDACs and HDAC inhibitors in the development and function of innate and adaptive immune cells and their implications for various diseases and therapies.
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影响因子：
3.1
作者：
Cosío BG;Jahn A;Iglesias A;Shafiek H;Busquets X;Agustí A
通讯作者：
Agustí A
影响因子：
5.8
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Bodas M;Mazur S;Min T;Vij N
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Vij N
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5.6
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Marson, Charles M.
影响因子：
20.3
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Buglio, Daniela;Khaskhely, Noor M.;Younes, Anas
通讯作者：
Younes, Anas
影响因子：
3.6
作者：
Alqinyah, Mohammed;Maganti, Nagini;Hooks, Shelley B.
通讯作者：
Hooks, Shelley B.