Controlled synthesis of amphiphilic biodegradable polylactide‐grafted dextran copolymers
Controlled synthesis of amphiphilic biodegradable polylactide‐grafted dextran copolymers
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DOI：
10.1002/pola.20100
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发表时间：
2004-06
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影响因子：
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通讯作者：
C. Nouvel;P. Dubois;E. Dellacherie;J. Six
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文献类型：
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作者：
C. Nouvel;P. Dubois;E. Dellacherie;J. Six
实现了新型两亲性聚丙交酯（PLA）接枝葡聚糖共聚物的全控合成。对这种可生物降解且具有潜在生物相容性的共聚物结构的控制需要基于“接枝”概念的三步合成。第一步包括葡聚糖羟基的部分甲硅烷基化。该保护步骤之后是部分甲硅烷基化多糖的剩余 OH 官能团引发的 D,L-丙交酯的开环聚合。第三步涉及在非常温和的条件下进行甲硅烷基醚基团的脱保护。在前人研究实现第一步控制的基础上，本研究重点关注后两步。研究了实验条件，以确保 D,L-丙交酯在接枝效率、接枝长度和酯交换限制方面的受控聚合。聚合后，研究了最后一步以避免多糖主链和聚酯接枝物的降解。在合成的每个步骤中检查葡聚糖主链的化学稳定性。 PLA 接枝葡聚糖和 PLA 接枝（硅烷化葡聚糖）已被证明在各种溶剂中采用核壳构象。此外，还对这些两亲接枝共聚物作为液/液界面稳定剂的潜在用途进行了初步实验。 © 2004 Wiley periodicals, Inc. J Polym Sci A 部分：Polym Chem 42：2577–2588，2004 年
The whole controlled synthesis of novel amphiphilic polylactide (PLA)-grafted dextran copolymers was achieved. The control of the architecture of such biodegradable and potentially biocompatible copolymers has required a three-step synthesis based on the “grafting from” concept. The first step consisted of the partial silylation of the dextran hydroxyl groups. This protection step was followed by the ring-opening polymerization of D,L-lactide initiated from the remaining OH functions of the partially silylated polysaccharide. The third step involved the silylether group deprotection under very mild conditions. Based on previous studies, in which the control of the first step was achieved, this study is focused on the last two steps. Experimental conditions were investigated to ensure a controlled polymerization of D,L-lactide, in terms of grafting efficiency, graft length, and transesterification limitation. After polymerization, the final step was studied in order to avoid degradation of both polysaccharide backbone and polyester grafts. The chemical stability of dextran backbone was checked throughout each step of the synthesis. PLA-grafted dextrans and PLA-grafted (silylated dextrans) were proved to adopt a core-shell conformation in various solvents. Furthermore, preliminary experiments on the potential use of these amphiphilic grafted copolymers as liquid/liquid interface stabilizers were performed. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 2577–2588, 2004