Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin.
Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin.
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DOI：
10.1016/0006-2952(91)90296-h
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发表时间：
1991-08
影响因子：
5.8
通讯作者：
Q. Wang;S. Giri;D. Hyde;C. Li
中科院分区：
文献类型：
--
作者：
Q. Wang;S. Giri;D. Hyde;C. Li
苯妥英已知可通过氧化芳烃中间体代谢形成对羟基苯基苯基苯妥英。反应性环氧芳烃可以不可逆地与大分子结合并引起毒性。本研究发现，高浓度丙戊酸可增加苯妥英与大鼠肝微粒体的不可逆结合。其作用与TCPO相似，可通过添加谷胱甘肽逆转。丙戊酸可增加苯妥英的肝毒性。
Phenytoin is known to be metabolized to form p-hydroxyphenyl-phenyl-hydantoin, possibly via the arene oxide intermediate. The reactive arene oxide may bind to macromolecules irreversibly and cause toxicity. In this study, valproic acid was found to increase the irreversible binding of phenytoin to rat liver microsomes at high concentrations. The effect was similar to that of TCPO and could be reversed by adding glutathione. Valproic acid may increase the hepatotoxicity of phenytoin.