SEQUENTIAL CEREBROSPINAL-FLUID AND PLASMA SAMPLING IN HUMANS - 24-HOUR MELATONIN MEASUREMENTS IN NORMAL SUBJECTS AND AFTER PERIPHERAL SYMPATHECTOMY
SEQUENTIAL CEREBROSPINAL-FLUID AND PLASMA SAMPLING IN HUMANS - 24-HOUR MELATONIN MEASUREMENTS IN NORMAL SUBJECTS AND AFTER PERIPHERAL SYMPATHECTOMY
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DOI：
10.1210/jcem-72-4-819
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发表时间：
1991-04-01
影响因子：
5.8
通讯作者：
OLDFIELD, E
中科院分区：
文献类型：
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作者：
BRUCE, J;TAMARKIN, L;OLDFIELD, E
同时测量血浆和脑脊液（CSF）褪黑激素和尿排泄的6-羟基褪黑激素在4名正常志愿者和1例患者前和后上胸交感神经切除术控制原发性多汗症。对于正常个体，血浆和CSF中每小时24小时褪黑激素浓度表现出类似的特征，白天低水平，夜间高水平。血浆峰值水平为122-660 pmol/L，CSF峰值水平为94-355 pmol/L。每个人的夜间褪黑激素增加的发病时间并不相同。尿6-羟基褪黑激素水平也表现出每日节律，在夜间排泄高峰。具有最低夜间循环褪黑激素水平的个体也具有最低的6-hydroxymelatonin.In多汗症患者的排泄，在术前CSF和血浆中观察到显著的褪黑激素节律。双侧T1-T2神经节切除后，褪黑激素水平显着降低，昼夜节律被取消。这些结果提供了直接的证据，在人类的昼夜褪黑激素节律的CSF和血浆，以及调节这种节奏的交感神经支配。
Simultaneous measurements of plasma and cerebrospinal fluid (CSF) melatonin and urinary excretion of 6-hydroxymelatonin were performed in four normal volunteers and one patient before and after upper thoracic sympathectomy for the control of essential hyperhidrosis. For normal individuals, hourly 24-h melatonin concentrations in plasma and CSF exhibited similar profiles, with low levels during the day and high levels at night. Peak plasma levels varied from 122-660 pmol/L, and the peak CSF levels from 94-355 pmol/L. The onset of the nocturnal increase in melatonin did not occur at the same time for each individual. Urinary 6-hydroxymelatonin levels also exhibited a daily rhythm, with peak excretion at night. The individual with the lowest nocturnal levels of circulating melatonin also had the lowest excretion of 6-hydroxymelatonin.In the patient with hyperhidrosis, a prominent melatonin rhythm was observed preoperatively in the CSF and plasma. After bilateral T1-T2 ganglionectomy, however, melatonin levels were markedly reduced, and the diurnal rhythm was abolished. These results provide direct evidence in humans for a diurnal melatonin rhythm in CSF and plasma as well as regulation of this rhythm by sympathetic innervation.