A MACROPHAGE-DERIVED FACTOR REQUIRED BY PLASMACYTOMAS FOR SURVIVAL AND PROLIFERATION INVITRO
A MACROPHAGE-DERIVED FACTOR REQUIRED BY PLASMACYTOMAS FOR SURVIVAL AND PROLIFERATION INVITRO
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DOI：
10.1126/science.3726549
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发表时间：
1986-08-01
期刊：
影响因子：
56.9
通讯作者：
POTTER, M
中科院分区：
文献类型：
--
作者：
NORDAN, RP;POTTER, M
浆细胞瘤 (PCT) 细胞系的增殖和存活依赖于小鼠巨噬细胞系 P388D1 所产生的因子，是在体外建立的。由降植烷诱导的贴壁腹膜细胞在体外产生的这种活性比常驻细胞多 50 倍。负责浆细胞瘤生长的分子不同于许多特征因子，包括白细胞介素-1、-2和-3、巨噬细胞集落刺激因子、B细胞刺激因子-1、B细胞生长因子II、表皮生长因子、转化生长因子-β、以及γ-和β-干扰素，它们均不能支持因子依赖性PCT细胞系的生长。这些结果表明PCT生长因子可能是一种以前未曾表征过的新因子，而且其产生与降植烷诱导的浆细胞瘤形成之前的慢性腹膜炎症反应有关。
Plasmacytoma (PCT) cell lines dependent for proliferation and survival on a factor elaborated by the murine macrophage cell line, P388D1, were established in vitro. Adherent peritoneal cells induced by pristane produced 50-fold greater amounts of this activity in vitro than did resident cells. The molecules responsible for plasmacytoma growth were distinct from a number of characterized factors including interleukin-1, -2, and -3, macrophage colony-stimulating factor, B-cell stimulatory factor-1, B-cell growth factor II, epidermal growth factor, transforming growth factor-.beta., and .gamma.- and .beta.-interferon, none of which were able to support the growth of the factor-dependent PCT cell lines. These results suggest that PCT growth factor may be a novel factor that has not been previously characterized and, further, that its production is associated with the pristane-induced, chronic peritoneal inflammatory response that precedes plasmacytoma formation.