Duration discrimination in the mouse (Mus musculus)
Duration discrimination in the mouse (Mus musculus)
复制标题
DOI：
10.1007/s00359-004-0561-0
复制
发表时间：
2004-12-01
影响因子：
2.1
通讯作者：
Klump, GM
中科院分区：
文献类型：
--
作者：
Klink, KB;Klump, GM
使用Go/NoGo程序和恒定刺激方法在NMRI小鼠中确定10 kHz纯音持续时间增量的检测阈值。获得了50、100和200 ms参考持续时间的持续时间，将信号呈现为固定电平或变化+/-3 dB的电平。使用信号检测理论（d' = 1.0或d' = 1.8）和50%正确响应的标准来确定阈值。对于固定水平，平均韦伯分数Δ T/T（d ′ = 1.8的标准）分别从50或100 ms的参考持续时间的1.18或1.23显著降低到200 ms的参考持续时间的0.97。对于阈值标准d ′ = 1或50%正确响应，分别水平随机化对辨别阈值没有影响。NMRI小鼠的持续时间辨别不遵循韦伯定律。结果与在刺激持续时间内总结神经冲动的机制一致。将心理声学数据与Brand等人（J Acoust Soc Am 51：1291 - 1223，2000）获得的关于小鼠下丘中声学信号持续时间的表示的结果进行比较。
Detection thresholds for an increment in duration of a 10-kHz pure tone were determined in the NMRI mouse using a Go/NoGo-procedure and the method of constant stimuli. Thresholds for reference durations of 50, 100 and 200 ms were obtained presenting the signals at a fixed level or at a level varying by +/- 3 dB. Thresholds were determined using signal-detection theory (d' = 1.0 or d' = 1.8) and the criterion of 50% correct responses. For a fixed level, the average Weber fraction DeltaT/T ( criterion of d' = 1.8) significantly decreased from 1.18 or 1.23 at reference durations of 50 or 100 ms, respectively, to 0.97 at a reference duration of 200 ms. Thresholds were on average reduced by 46.8 or 55.4% for the threshold criteria d' = 1 or 50% correct responses, respectively. There was no effect of randomizing the level on the discrimination threshold. Duration discrimination in the NMRI mouse does not follow Weber's law. The results are consistent with a mechanism summing up neural impulses over the duration of the stimulus. The psychoacoustic data are compared with results obtained by Brand et al. ( J Acoust Soc Am 51: 1291 - 1223, 2000) on the representation of acoustic signal duration in the mouse inferior colliculus.