HELPER FUNCTION OF T7 PROTEIN KINASE IN VIRUS PROPAGATION
HELPER FUNCTION OF T7 PROTEIN KINASE IN VIRUS PROPAGATION
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DOI：
10.1038/255508a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
SCHWEIGER, M
中科院分区：
文献类型：
--
作者：
HIRSCHKAUFFMANN, M;HERRLICH, P;SCHWEIGER, M
用噬菌体T7或T3感染大肠杆菌后，可诱导一种蛋白激酶，其遗传信息由噬菌体编码（参考文献1）。蛋白激酶在基因表达的调节中是重要的，因为它抑制E. coliRNA聚合酶，并且它将T7基因组的宿主依赖性转录限制在早期区域2。T7蛋白激酶磷酸化E. coliRNA聚合酶（这一作用解释了对转录的影响）和其他。大肠杆菌蛋白1，2.
A PROTEIN kinase, the genetic information for which is phage-coded, is induced after infection ofEscherichia coliwith either phage T7 or T3 (ref. 1). The protein kinase is important in the regulation of gene expression in that it inhibits the initiation of transcription byE. coliRNA polymerase and in that it restricts host-dependent transcription of the T7 genome to the early region2. T7 protein kinase phosphorylates the β′ subunit ofE. coliRNA polymerase (this action provides an explanation for the effects on transcription) and otherE. coliproteins1,2.