Polyphenols: skin photoprotection and inhibition of photocarcinogenesis.
Polyphenols: skin photoprotection and inhibition of photocarcinogenesis.
复制标题
DOI：
10.2174/13895575111091200
复制
发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Katiyar SK
中科院分区：
文献类型：
--
作者：
Afaq F;Katiyar SK
多酚是天然植物产物的一大家族，广泛分布于植物性食品中，如水果、蔬菜、坚果、花卉、树皮和种子等。这些多酚有助于膳食产品的有益健康作用。临床和流行病学研究表明，皮肤暴露于环境因素/污染物，如太阳紫外线（UV）辐射会引起有害影响，并导致各种皮肤病，包括黑色素瘤和非黑色素瘤皮肤癌的风险。包括鳞状细胞癌和基底细胞癌的非黑色素瘤皮肤癌的发病率是全球范围内重要的公共卫生问题。皮肤暴露于太阳紫外线辐射导致炎症、氧化应激、DNA损伤、细胞信号传导途径的失调和免疫抑制，从而导致皮肤癌。定期摄入天然植物产品，特别是多酚，广泛存在于水果，蔬菜，干豆类和饮料中，作为抵御紫外线辐射不利影响的保护剂，已获得相当大的关注。本文首先从多酚类化合物的构效关系和生物利用度两个方面讨论了多酚类化合物对人体健康的影响。然后，我们详细讨论了一些选定的多酚类化合物对紫外线诱导的皮肤炎症，增殖，免疫抑制，DNA损伤和失调的重要细胞信号通路及其在皮肤癌管理的影响的光保护作用。选择的多酚包括：绿色茶多酚、石榴果提取物、葡萄籽原花青素、白藜芦醇、水飞蓟素、染料木素和飞燕草素。关于这些多酚的作用机制的新信息支持它们在皮肤光保护和预防人类光致癌中的潜在用途。
Polyphenols are a large family of naturally occurring plant products and are widely distributed in plant foods, such as, fruits, vegetables, nuts, flowers, bark and seeds, etc. These polyphenols contribute to the beneficial health effects of dietary products. Clinical and epidemiological studies suggest that exposure of the skin to environmental factors/pollutants, such as solar ultraviolet (UV) radiation induce harmful effects and leads to various skin diseases including the risk of melanoma and non-melanoma skin cancers. The incidence of non-melanoma skin cancer, comprising of squamous cell carcinoma and basal cell carcinoma, is a significant public health concern world-wide. Exposure of the skin to solar UV radiation results in inflammation, oxidative stress, DNA damage, dysregulation of cellular signaling pathways and immunosuppression thereby resulting in skin cancer. The regular intake of natural plant products, especially polyphenols, which are widely present in fruits, vegetables, dry legumes and beverages have gained considerable attention as protective agents against the adverse effects of UV radiation. In this article, we first discussed the impact of polyphenols on human health based on their structure-activity relationship and bioavailability. We then discussed in detail the photoprotective effects of some selected polyphenols on UV-induced skin inflammation, proliferation, immunosuppression, DNA damage and dysregulation of important cellular signaling pathways and their implications in skin cancer management. The selected polyphenols include: green tea polyphenols, pomegranate fruit extract, grape seed proanthocyanidins, resveratrol, silymarin, genistein and delphinidin. The new information on the mechanisms of action of these polyphenols supports their potential use in skin photoprotection and prevention of photocarcinogenesis in humans.