N-acetyl aspartate levels in adolescents with bipolar and/or cannabis use disorders.
N-acetyl aspartate levels in adolescents with bipolar and/or cannabis use disorders.
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DOI：
10.1080/15504263.2013.869077
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发表时间：
2014
影响因子：
2.2
通讯作者：
DelBello MP
中科院分区：
文献类型：
--
作者：
Bitter SM;Weber WA;Chu WJ;Adler CM;Eliassen JC;Strakowski SM;DelBello MP
Bipolar and cannabis use disorders commonly co-occur during adolescence, and neurochemical studies may help clarify the pathophysiology underlying this co-occurrence. This study compared metabolite concentrations in the left ventral lateral prefrontal cortex among: adolescents with bipolar disorder (bipolar group; n=14), adolescents with a cannabis use disorder (cannabis use group, n=13), adolescents with cannabis use and bipolar disorders (bipolar and cannabis group, n=25), and healthy adolescents (healthy controls, n=15). We hypothesized that adolescents with bipolar disorder (with or without cannabis use disorder) would have decreased N-acetyl aspartate levels in the ventral lateral prefrontal cortex compared to the other groups, and that the bipolar and cannabis group would have the lowest N-acetyl aspartate levels of all groups. N-acetyl aspartate concentrations in the left ventral lateral prefrontal cortex were obtained using Proton Magnetic Resonance Spectroscopy. Adolescents with bipolar disorder showed significantly lower left ventral lateral prefrontal cortex N-acetyl aspartate levels, but post-hoc analyses indicated that this was primarily due to increased N-acetyl aspartate levels in the cannabis group. The cannabis use disorder group had significantly higher N-acetyl aspartate levels compared to the bipolar disorder and the bipolar and cannabis groups (p=0.0002 and p=0.0002, respectively). Pearson correlations revealed a significant positive correlation between amount of cannabis used and N-acetyl aspartate concentrations. Adolescents with cannabis use disorder showed higher levels of N-acetyl aspartate concentrations that were significantly positively associated with the amount of cannabis used; however, this finding was not present in adolescents with comorbid bipolar disorder.
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影响因子：
2.2
作者：
Black JJ;Heffner JL;Anthenelli RM;Beavers JN;Albertz A;Blom T;Adler C;Delbello MP
通讯作者：
Delbello MP
影响因子：
7.6
作者：
DelBello, Melissa P.;Cecil, Kim M.;Strakowski, Stephen M.
通讯作者：
Strakowski, Stephen M.
影响因子：
64.8
作者：
Panikashvili, D;Simeonidou, C;Shohami, E
通讯作者：
Shohami, E
影响因子：
5.7
作者：
Prescot, Andrew P.;Locatelli, Allison E.;Renshaw, Perry F.;Yurgelun-Todd, Deborah A.
通讯作者：
Yurgelun-Todd, Deborah A.
影响因子：
10.6
作者：
Patel, Nick C.;DelBello, Melissa P.;Strakowski, Stephen M.
通讯作者：
Strakowski, Stephen M.