Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry
Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry
复制标题
DOI：
10.1021/ja402586c
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发表时间：
2013-06-26
影响因子：
15
通讯作者：
Otto, Sijbren
中科院分区：
文献类型：
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作者：
Li, Jianwei;Nowak, Piotr;Otto, Sijbren
动态组合化学（DCC）是组合化学的一个子集，其中文库成员通过彼此交换结构单元而连续地相互转化。动态组合库（DCL）是发现意外的强大工具，并产生了许多迷人的分子，从互锁结构到自我复制因子。此外，动态组合分子网络可以在系统水平上产生涌现性质，这为系统化学提供了令人兴奋的新机遇。在这个角度来看，我们将突出在这一领域的一些新的方法，并分析选定的例子，DCL的热力学控制下，导致合成受体，催化系统，和复杂的自组装超分子结构。还审查了DCC的原则，不处于平衡状态，因此可能会窝藏更丰富的功能行为的系统的扩展。例子包括自我复制和分子机器。
Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other. Dynamic combinatorial libraries (DCLs) are powerful tools for discovering the unexpected and have given rise to many fascinating molecules, ranging from interlocked structures to self-replicators. Furthermore, dynamic combinatorial molecular networks can produce emergent properties at systems level, which provide exciting new opportunities in systems chemistry. In this perspective we will highlight some new methodologies in this field and analyze selected examples of DCLs that are under thermodynamic control, leading to synthetic receptors, catalytic systems, and complex self-assembled supramolecular architectures. Also reviewed are extensions of the principles of DCC to systems that are not at equilibrium and may therefore harbor richer functional behavior. Examples include self-replication and molecular machines.