Female Patients Require a Higher Propofol Infusion Rate for Sedation.
Female Patients Require a Higher Propofol Infusion Rate for Sedation.
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DOI：
10.2344/0003-3006-63.2.67
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发表时间：
2016-01-01
影响因子：
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通讯作者：
Miyawaki, Takuya
中科院分区：
文献类型：
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作者：
Maeda, Shigeru;Tomoyasu, Yumiko;Miyawaki, Takuya
镇静可以最大限度地减少生理和行为应激反应。在我们的设施中，丙泊酚的输注速率根据脑电双频指数（BIS）在所有植入相关手术的情况下进行调整;回顾性数据的多变量分析使我们能够提取影响丙泊酚镇静剂量的独立因素，这些因素被认为是实现充分镇静的有用指标。研究人群包括2009年4月至2013年3月在冈山大学医院接受静脉镇静下植入相关手术的所有患者。调整丙泊酚输注速率，使BIS值维持在70-80。结果是丙泊酚的平均输注速率，潜在的预测变量是年龄、性别、体重、治疗时间和咪达唑仑的量。多元回归分析提取影响丙泊酚平均输注速率的自变量。入组了125例受试者。在多元回归分析中，女性性别与较高的丙泊酚平均输注速率显著相关。在进行植入物相关手术时，女性可能需要比男性更高的丙泊酚输注速率以实现充分的镇静。
Sedation may minimize physiologic and behavioral stress responses. In our facility, the infusion rate of propofol is adjusted according to the bispectral index (BIS) in all cases of implant-related surgery; multivariate analysis of retrospective data enabled us to extract independent factors that affect the dose of propofol in sedation that are considered useful indicators for achieving adequate sedation. The study population comprised all patients undergoing implant-related surgery under intravenous sedation in Okayama University Hospital from April 2009 to March 2013. The infusion rate of propofol was adjusted to maintain the BIS value at 70-80. The outcome was the average infusion rate of propofol, and potential predictor variables were age, sex, body weight, treatment time, and amount of midazolam. Independent variables that affected the average infusion rate of propofol were extracted with multiple regression analysis. One hundred twenty-five subjects were enrolled. In the multiple regression analysis, female sex was shown to be significantly associated with a higher average infusion rate of propofol. Females may require a higher infusion rate of propofol than males to achieve adequate sedation while undergoing implant-related surgery.