Modulation of the inflammatory response in the rat TMJ with increasing doses of complete Freund's adjuvant
Modulation of the inflammatory response in the rat TMJ with increasing doses of complete Freund's adjuvant
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DOI：
10.1053/joca.2001.0461
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发表时间：
2001-10-01
影响因子：
7
通讯作者：
Bellinger, LL
中科院分区：
文献类型：
--
作者：
Harper, RP;Kerins, CA;Bellinger, LL
目的：急性炎症会给生理系统带来压力，生理系统必须做出反应才能重建体内平衡。本研究的目的是确定双侧颞下颌关节（TMJ）注射不同剂量的弗氏完全佐剂（CFA）是否会产生急性炎症生物标志物的剂量依赖性变化。建立具有不同程度关节炎症的动物模型的能力将允许评估可以调节疾病严重程度的药物或条件。 设计：三组雄性 Sprague-Dawley 大鼠的 TMJ 注射含有不同剂量结核分枝杆菌 (MT) 的 CFA。将一组未注射的大鼠和一组注射生理盐水的大鼠作为对照，每天记录进食量、体重、肿胀和色素漏。注射后48小时测定白细胞介素1β（IL-1β）和皮质酮水平，并测量髁突软骨厚度。结果：注射后24小时，双侧颞下颌关节肿胀和色素漏明显（P
Objectives: Acute inflammation stresses the physiological system, which must respond in order to reestablish homeostasis. The purpose of this study was to determine whether bilateral temporomandibular joint (TMJ) injections of different doses of Complete Freund's Adjuvant (CFA) produced dose-dependent changes in biologic markers of acute inflammation. The ability to establish an animal model with varying degrees of joint inflammation would allow evaluation of agents or conditions that could modulate the severity of the disease.Design: The TMJs of three groups of male Sprague-Dawley rats were injected with CFA containing varying doses of Mycobacterium tuberculosis (MT). A group of non-injected and a group of saline injected rats were used as controls, Food intake, body weights, swelling and chromodacryorrhea were recorded daily. Interleukin-1 beta (IL-1 beta) and corticosterone levels were assayed and condylar cartilage thickness was measured 48 h after injections.Results: Twenty-four hours post-injection, bilateral TMJ swelling and chromodacryorrhea were significantly (P