Three-dimensional microimaging (MRμI and μCT), finite element modeling, and rapid prototyping provide unique insights into bone architecture in osteoporosis
Three-dimensional microimaging (MRμI and μCT), finite element modeling, and rapid prototyping provide unique insights into bone architecture in osteoporosis
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DOI：
10.1002/ar.1060
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发表时间：
2001-04-15
影响因子：
--
通讯作者：
Sod, EW
中科院分区：
文献类型：
--
作者：
Borah, B;Gross, GJ;Sod, EW
随着许多国家老年人比例的增加，骨质疏松症已成为一个日益严重的公共卫生问题，并带来日益严重的医疗、社会和经济后果。众所周知，低骨量和骨小梁结构的恶化是骨质疏松性骨折的基础。全面了解骨量、骨的三维（3D）结构和骨功能之间的关系是研究骨质疏松症新疗法和现有疗法的基础。使用高分辨率数字成像技术，如磁共振显微成像（MR穆尔）、微计算机断层扫描（mu CT）和直接图像分析，对3D小梁结构进行详细分析，直到最近才变得可行。快速成型技术用于在宏观上复制复杂的骨小梁结构，以进行视觉或生物力学分析。此外，一套完整的3D图像数据为有限元建模（FEM）提供了基础，以预测机械性能。本文的目的是描述我们如何能够整合三维显微成像和图像分析技术，定量的骨小梁结构，有限元虚拟生物力学，快速原型增强可视化。这些技术的整合为我们提供了一种独特的能力，以研究骨结构在骨质疏松性骨折中的作用，并支持新疗法的发展。Anat Rec（New Anat）265：101-110 2001. (C)2001 Wiley-Liss，Inc.
With the proportion of elderly people increasing in many countries, osteoporosis has become a growing public health problem, with rising medical, social, and economic consequences. It is well recognized that a combination of low bone mass and the deterioration of the trabecular architecture underlies osteoporotic fractures. A comprehensive understanding of the relationships between bone mass, the three-dimensional (3D) architecture of bone and bone function is fundamental to the study of new and existing therapies for osteoporosis. Detailed analysis of 3D trabecular architecture, using high-resolution digital imaging techniques such as magnetic resonance microimaging (MR mul), micro-computed tomography (mu CT), and direct image analysis, has become feasible only recently. Rapid prototyping technology is used to replicate the complex trabecular architecture on a macroscopic scare for visual or biomechanical analysis. Further, a complete set of 3D image data provides a basis for finite element modeling (FEM) to predict mechanical properties. The goal of this paper is to describe how we can integrate three-dimensional microimaging and image analysis techniques for quantitation of trabecular bone architecture, FEM for virtual biomechanics, and rapid prototyping for enhanced visualization. The integration of these techniques provide us with an unique ability to investigate the role of bone architecture in osteoporotic fractures and to support the development of new therapies. Anat Rec (New Anat) 265:101-110 2001. (C) 2001 Wiley-Liss, Inc.