New insights into the cell biology of the marginal zone of the spleen.
New insights into the cell biology of the marginal zone of the spleen.
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DOI：
10.1016/s0074-7696(06)50005-1
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Mebius R
中科院分区：
文献类型：
--
作者：
Kraal G;Mebius R
在脾脏的边缘区，血流通过一个由网状细胞和纤维构成的开放系统，各种髓样细胞和淋巴细胞位于其中。该区域的巨噬细胞凭借模式识别受体的独特组合，能够很好地识别病原体并过滤血液。它们与一组特定的B细胞相互作用，这些B细胞仅存在于边缘区，尤其能够对细菌抗原迅速作出反应。这种位置具有战略意义的细胞组合是我们抵御血源性病原体的一个重要因素。本文结合脾脏在宿主防御中的功能，对边缘区本身以及边缘区B细胞发育的新数据进行了综述和讨论。
In the marginal zone of the spleen the bloodstream passes through an open system of reticular cells and fibers in which various myeloid and lymphoid cells are located. Macrophages in this region are well equipped to recognize pathogens and filter the blood by virtue of unique combinations of pattern recognition receptors. They interact with a specific set of B cells that can be found only in the marginal zone and that are able to react rapidly to bacterial antigens in particular. This combination of strategically located cells is an important factor in our defense against blood‐borne pathogens. New data on the development of the marginal zone itself and the marginal zone B cells are reviewed and discussed in light of the function of the spleen in host defense.