A comparison of 3 lasers and liquid nitrogen in the treatment of solar lentigines -: A randomized, controlled, comparative trial
A comparison of 3 lasers and liquid nitrogen in the treatment of solar lentigines -: A randomized, controlled, comparative trial
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DOI：
10.1001/archderm.136.7.841
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发表时间：
2000-07-01
影响因子：
--
通讯作者：
Hata, TR
中科院分区：
文献类型：
--
作者：
Todd, MM;Rallis, TM;Hata, TR
目的：确定激光治疗太阳能晶状体是否优于液氮，如果是，则确定一种激光是否优于其他被测试的激光。设计：随机、对照、对比研究。地点：大学皮肤科临床。参与者：27名双手背部有多个太阳能晶状体的患者。干预：液氮冷冻，Medlite II倍频Q开关Nd：YAG激光(加州利弗莫尔的Continuum Biomedical)，HGM KI氪激光(HGM医疗激光系统公司，犹他州盐湖城)，和DioLite 532 nm二极管泵浦的钒酸盐激光(Iridex公司，加利福尼亚州山景市)。主要观察指标：在治疗前以及治疗后6周和12周拍摄手部照片。盲人观察者和患者评估了每种治疗方法在不引起不良反应的情况下减轻色素病变的能力。结果：许多新的激光系统声称通过选择性地破坏黑色素来治疗色素病变具有优势。在本研究中，倍频调Q激光最有可能提供显著的照明效果(P
Objective: To determine if laser therapy is superior to liquid nitrogen for the treatment of solar lentigines and if so, to determine if one laser is superior to the other lasers that were tested.Design: Randomized, controlled, comparative study with blinded observers.Setting: University-based dermatology clinic.Participants: Twenty-seven patients with multiple solar lentigines on the backs of both hands.Interventions: Liquid nitrogen cryotherapy, the Medlite II frequency-doubled Q-switched Nd:YAG laser (Continuum Biomedical, Livermore, Calif), the HGM KI krypton laser (HGM Medical Laser Systems Inc, Salt Lake City, Utah), and the DioLite 532-nm diode-pumped vanadate laser (Iridex Corp, Mountain View, Calif).Main Outcome Measures: Photographs of the hands were taken prior to and 6 and 12 weeks following treatment. Blinded observers and patients evaluated each treatment on its ability to lighten pigmented lesions without causing unwanted adverse effects.Results: Many new laser systems claim an advantage for treating pigmented lesions by selectively destroying melanin. In this study, the frequency-doubled Q-switched Nd:YAG laser was most likely to provide significant lightening (P