EFFECT OF ALKALINE GLUTARALDEHYDE ON HEPATITIS-B VIRUS-ANTIGENS
EFFECT OF ALKALINE GLUTARALDEHYDE ON HEPATITIS-B VIRUS-ANTIGENS
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DOI：
10.1007/bf02019460
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发表时间：
1983-01-01
影响因子：
4.5
通讯作者：
MELNICK, JL
中科院分区：
文献类型：
--
作者：
ADLERSTORTHZ, K;SEHULSTER, LM;MELNICK, JL
The potential of alkaline 2 % glutaraldehyde solutions, with and without surface active agents, to alter the antigenicity of hepatitis B virus (HBV) was analyzed and compared to the antigenic alternation capacities of 0.525 % sodium hypochlorite and 2.02 % formaldehyde solutions. After treatment of a hepatitis B surface antigen-positive plasma at room temperature for 10 min, there was a 51–67 % reduction in surface antigen level and a 90–94 % decrease in hepatitis B core antigenicity. Glutaraldehyde is proposed as an alternative to the more noxious hypochlorite and formaldehyde solutions for disinfection of HBV-contaminated articles.
