Simple and efficient protocol for catalyst recycling and product recovery in the Pd-catalyzed homogeneous Suzuki reaction
Simple and efficient protocol for catalyst recycling and product recovery in the Pd-catalyzed homogeneous Suzuki reaction
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DOI：
10.1016/j.tetlet.2004.04.198
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发表时间：
2004-08-16
影响因子：
1.8
通讯作者：
Monteiro, AL
中科院分区：
文献类型：
--
作者：
Nobre, SM;Wolke, SI;Monteiro, AL
聚环氧乙烷（PEO）/甲醇可以用作温和条件下 Pd 催化的 Suzuki 交叉偶联反应的溶剂介质。反应结束后，用庚烷萃取产物，极性相可重复使用多次，活性不会发生任何变化。从非极性相中以优异的分离产率 (>90%) 获得纯联芳基产物。使用相同的含有催化剂的极性相来偶联不同的芳基卤化物，以良好到高的分离产率提供联芳基产物。 (C) 2004 Elsevier Ltd. 保留所有权利。
Poly(ethylene oxide) (PEO)/methanol can be used as solvent medium for the Pd-catalyzed Suzuki cross-coupling reaction under mild conditions. After the end of the reaction the product is extracted with heptane and the polar phase can be reused several times without any change in the activity. Pure biaryl products are obtained from the nonpolar phase in excellent isolated yields (>90%). The same catalyst-containing polar phase was used to coupling different aryl halides furnishing the biaryl products in good to high isolated yields. (C) 2004 Elsevier Ltd. All rights reserved.