Determinants that govern alternative splicing of parvovirus pre-mRNAs
Determinants that govern alternative splicing of parvovirus pre-mRNAs
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控制细小病毒前体 mRNA 选择性剪接的决定因素
DOI：
10.1006/smvy.1995.0034
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
J. Pearson
中科院分区：
文献类型：
--
作者：
D. Pintel;A. Gersappe;D. Haut;J. Pearson
摘要细小病毒广泛利用选择性剪接增加其紧凑基因组中重叠阅读框架的编码能力。最近，相当多的注意力已经支付给表征的决定因素，管理由小鼠细小病毒（MVM）产生的前mRNA的选择性剪接。这些研究表明，MVM选择性剪接受到内含子之间相互作用的因素和外显子内决定因素的影响。与其他自主细小病毒与已知的转录图的比较表明，这些决定因素可能发挥作用的手段。因此，细小病毒已成为一个有前途的，在某些方面新的，模型，了解哺乳动物细胞中的选择性剪接和外显子定义的过程。
Abstract Parvoviruses extensively utilize alternative splicing to increase the coding capacity from overlapping reading frames in their compact genomes. Recently, a considerable amount of attention has been paid to characterizing the determinants that govern alternative splicing of pre-mRNAs generated by the parvovirus minute virus of mice (MVM). These studies have revealed that MVM alternative splicing is governed both by factors interacting between introns and by determinants within exons. Comparison with other autonomous parvoviruses with known transcript maps suggest means by which such determinants may function. Parvoviruses have thus become a promising, and in some respects novel, model for understanding the process of alternative splicing and exon definition in mammalian cells.