In Situ Loading of Drugs into Mesoporous Silica SBA-15.
In Situ Loading of Drugs into Mesoporous Silica SBA-15.
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DOI：
10.1002/chem.201504532
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发表时间：
2016-04
期刊：
影响因子：
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通讯作者：
M. Wan;Y. Li;Tian-Bo Yang;Zhang Tao;X. Sun;J. Zhu
中科院分区：
文献类型：
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作者：
M. Wan;Y. Li;Tian-Bo Yang;Zhang Tao;X. Sun;J. Zhu
在一种将药物装载到介孔二氧化硅中的新策略中，亲水性（肝素）或疏水性药物（布洛芬）通过蒸发诱导自组装直接封装在一锅合成中。原位载药可以显著缩短制备时间，提高药物的载药量和释放分数，适当的药物添加剂有利于制备具有介孔结构的药物载体。通过FTIR光谱和释放测试验证药物负载，其显示与后负载SBA-15相比，使用更大量的肝素或布洛芬的释放时间长得多。此外，还对肝素的体外抗凝性能和血管的生物相容性进行了仔细的评估，包括活化部分凝血活酶时间、凝血酶时间、溶血、血小板粘附实验和红细胞形态学。提出了软核硬壳药物释放剂的概念，为新型药物释放系统的设计提供了指导。
In a new strategy for loading drugs into mesoporous silica, a hydrophilic (heparin) or hydrophobic drug (ibuprofen) is encapsulated directly in a one-pot synthesis by evaporation-induced self-assembly. In situ drug loading significantly cuts down the preparation time and dramatically increases the loaded amount and released fraction of the drug, and appropriate drug additives favor a mesoporous structure of the vessels. Drug loading was verified by FTIR spectroscopy and release tests, which revealed much longer release with a larger amount of heparin or ibuprofen compared to postloaded SBA-15. Besides, the in vitro anticoagulation properties of the released heparin and the biocompatibility of the vessels were carefully assessed, including activated partial thromboplastin time, thrombin time, hemolysis, platelet adhesion experiments, and the morphologies of red blood cells. A concept of new drug-release agents with soft core and hard shell is proposed and offers guidance for the design of novel drug-delivery systems.