Catalytic enantioselective Diels-Alder reaction by self-assembly of the components on a Lewis acid template
Catalytic enantioselective Diels-Alder reaction by self-assembly of the components on a Lewis acid template
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DOI：
10.1021/ol051262e
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发表时间：
2005-08-04
期刊：
影响因子：
5.2
通讯作者：
Souweha, MS
中科院分区：
文献类型：
--
作者：
Ward, DE;Souweha, MS
2,4-己二醇与丙烯酸甲酯的热Diels-Alder反应是无选择性的。通过将二烯和亲二烯试剂与手性双金属路易斯酸催化剂同时配位，LACASA-DA反应的发生完全控制了区域、非映体和对映体的选择性，得到了单一的加合物。
Thermal Diels-Alder reaction of 2,4-hexadienol with methyl acrylate is unselective. By simultaneous coordination of diene and dienophile to a chiral bimetallic Lewis acid catalyst, a LACASA-DA reaction occurs with complete control of regio-, diastereo-, and enantioselectivity to give a single adduct.