Circulating persistent organic pollutants and body fat distribution: Evidence from NHANES 1999-2004.
Circulating persistent organic pollutants and body fat distribution: Evidence from NHANES 1999-2004.
复制标题
DOI：
10.1002/oby.21161
复制
发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Sun Q
中科院分区：
文献类型：
--
作者：
Zong G;Grandjean P;Wu H;Sun Q
评价和比较各种循环持久性有机污染物（POP）与双能X线吸收法测量的躯干、腿部和全身脂肪质量百分比（FM%）的相关性。该研究纳入了1999-2004年国家健康和营养调查中的2358名成年人（≥20岁）。在调整主要混杂因素（包括年龄、吸烟状况、哺乳史和产次）后，计算偏皮尔逊相关系数。沃尔夫的方法被用来比较来自相同的参与者的相关系数。12个持久性有机污染物显示出显着不同的相关性与躯干和腿部地区的脂肪库。β-六氯环己烷、七氯二苯并对二恶英、八氯二苯并对二恶英和多氯联苯（PCB）-126与树干FM%的正相关性强于与腿FM%的正相关性，而氯≥6的PCB与树干FM%的负相关性强于与腿FM %的负相关性。分层分析显示，主要在<40岁的参与者中，POP与躯干FM%之间存在较强的负相关性，而在老年参与者中观察到POP与躯干FM%之间存在较强的正相关性。与腿部脂肪相比，持久性有机污染物与躯干脂肪之间的关联性更强，这可能表明躯干脂肪在持久性有机污染物的药代动力学中的作用更重要，或者持久性有机污染物作为内分泌干扰物对躯干脂肪代谢的影响更大。
To evaluate and compare the correlations of various circulating persistent organic pollutants (POPs) with fat mass percentages (FM%) of trunk, leg, and whole body measured by Dual-energy X-ray absorptiometry. This study included 2358 adults (≥20 years) in the National Health and Nutrition Examination Survey 1999-2004. Partial Pearson correlation coefficients were calculated, after adjusting for major confounders, including age, smoking status, and history of lactation and parity. Wolfe's method was used to compare correlation coefficients derived from the same participants. Twelve POPs showed significantly different correlations with fat depots in trunk and leg regions. β-hexachlorocyclohexane, heptachlorodibenzo-p-dioxin, and octachlorodibenzo-p-dioxin, and polychlorinated biphenyl (PCB)-126 showed stronger positive correlations with trunk FM% than with leg FM%, whereas PCBs with ≥6 chlorines were more inversely correlated with trunk FM% than leg FM%. Age-stratified analysis showed stronger inverse correlations between POPs and trunk FM% mainly in participants <40 years, whereas stronger positive correlations between POPs and trunk FM% were observed in older participants. Stronger associations between POPs and trunk fat as compared to leg fat, possibly indicated a more important role of trunk fat in the pharmacokinetics of POPs, or a stronger effect of POPs, as endocrine disruptors, on trunk fat metabolism.