Prevalence of dementia and main subtypes in rural northern China.
Prevalence of dementia and main subtypes in rural northern China.
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中国北部农村痴呆症和主要亚型的患病率。
DOI：
10.1159/000375366
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发表时间：
2015
影响因子：
2.4
通讯作者：
Wisniewski T
中科院分区：
文献类型：
--
作者：
Ji Y;Shi Z;Zhang Y;Liu S;Liu S;Yue W;Liu M;Huo YR;Wang J;Wisniewski T
本研究的目的是评估中国北部农村居民痴呆、阿尔茨海默病(AD)和血管性痴呆(VAD)的患病率，并确定其社会人口学危险因素。2011年至2012年，对居住在中国北部农村的60岁≥居民进行了痴呆、AD和VaD症状的临床评估。诊断是使用既定标准和标准程序进行的。在5,578名60岁的≥登记研究参与者中，痴呆症、AD和VaD的患病率分别为7.7%、5.4%和1.7%。高龄(OR=1.17；95%CI：1.14~1.19)和女性(OR=2.13；95%CI：1.51~3.00)是AD的独立危险因素。高文化程度(OR=0.36；95%CI：0.21~0.6)和参与社会活动(OR=0.219；95%CI：0.163~0.295)是保护性因素。与VaD相关的危险因素有年龄(OR=1.11；95%CI：1.1~1.12)和高血压(OR=1.83；95%CI：1.18~2.86)，高学历(OR=0.53，95%CI：0.44~0.65)和参加社会活动(OR=0.34；95%CI：0.29~0.41)是保护因素。中国北部农村痴呆(7.7%)和阿尔茨海默病(5.4%)患病率较高。高龄和女性是AD的危险因素，高龄和高血压是VaD的危险因素。较高的教育水平和参加社会活动被确定为预防AD和VaD的保护因素。
The aim of this article was to estimate the prevalence of and to determine the sociodemographic risk factors for dementia, Alzheimer’s disease (AD) and vascular dementia (VaD) among individuals residing in rural northern China. Between 2011 and 2012, residents aged ≥ 60 years and residing in rural areas of northern China were clinically assessed for symptoms of dementia, AD and VaD. Diagnoses were made using established criteria and standard procedures. Among 5,578 enrolled study participants aged ≥ 60 years, the prevalence rates of dementia, AD and VaD were 7.7, 5.4 and 1.7%, respectively. Older age (OR = 1.17; 95% CI: 1.14–1.19) and female gender (OR = 2.13; 95% CI: 1.51–3.00) were identified as independent risk factors for AD. In turn, a higher educational level (OR = 0.36; 95% CI: 0.21–0.60) and engagement in social activities (OR = 0.219; 95% CI: 0.163–0.295) were protective factors. Risk factors associated with VaD were older age (OR = 1.11; 95% CI: 1.1– 1.12) and hypertension (OR = 1.83; 95% CI: 1.18–2.86), while a higher educational level (OR = 0.53, 95% CI: 0.44–0.65) and engagement in social activities (OR = 0.34; 95% CI: 0.29–0.41) were protective factors. High rates of dementia (7.7%) and AD (5.4%) were found in the rural areas of northern China. Older age and female gender were identified as risk factors for AD, while older age and hypertension were risk factors for VaD. A higher educational level and engagement in social activities were identified as protective factors against both AD and VaD.