The interrelationship between the release of renin and vasopressin as defined by orthostasis and propranolol.
The interrelationship between the release of renin and vasopressin as defined by orthostasis and propranolol.
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由直立性和普萘洛尔定义的肾素和加压素释放之间的相互关系。
DOI：
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发表时间：
1977
影响因子：
15.9
通讯作者：
J. Slater
中科院分区：
文献类型：
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作者：
R. Davies;M. Forsling;J. Slater
正常人在85 °头高位倾斜后血浆肾素和精氨酸加压素浓度均升高。血浆肾素活性，增加了70-80%以上的仰卧值，是最大的在15或30分钟，而血浆精氨酸加压素浓度的6 - 7倍的增加，观察到30和45分钟之间。静脉注射普萘洛尔倾斜前管理被用来调查的可能性，精氨酸加压素的延迟上升是由肾素刺激。虽然血浆肾素的反应被普萘洛尔完全消除，加压素的反应不受影响。这些结果表明，血管加压素的释放后，实现直立等渗性低血容量可能会发生独立的变化，在肾素-血管紧张素系统中的普萘洛尔的存在。
The concentration of both plasma renin and plasma arginine vasopressin rose in normal subjects after an 85 degrees head-up tilt. Plasma renin activity, which increased 70-80% above the supine value, was maximal at 15 or 30 min, whereas the six- to seven-fold increase of plasma arginine vasopressin concentration was observed between 30 and 45 min. Intravenous propranolol administered just before tilt was used to investigate the possibility that the delayed rise of arginine vasopressin was stimulated by renin. Although the response of plasma renin was completely abolished by propranolol, the response of vasopressin was unaffected. These findings suggest that the release of vasopressin that follows isosmolar hypovolemia achieved by orthostasis may occur independently of changes in the renin-angiotensin system in the presence of propranolol.