Behavioural effects in mice orally exposed to domoic acid or ibotenic acid are influenced by developmental stages and sex differences
Behavioural effects in mice orally exposed to domoic acid or ibotenic acid are influenced by developmental stages and sex differences
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口服软骨藻酸或鹅膏蕈酸对小鼠的行为影响受到发育阶段和性别差异的影响
DOI：
10.1016/j.bbrc.2021.04.080
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发表时间：
2021
影响因子：
3.1
通讯作者：
*Tanemura K
中科院分区：
文献类型：
--
作者：
Sasaki T;Saito H;Hiradate Y;Hara K;*Tanemura K
大脑的结构在关键时期发生了巨大的变化。生理物质（神经递质、激素等）在性成熟前后，体内的激素水平波动很大。因此，化学品暴露对中枢神经系统的影响往往因发育阶段和性别而异。我们的目的是比较不同生命阶段（未成熟或成熟）和不同性别（雄性或雌性）的小鼠给予化学品后产生的行为影响。我们给小鼠注射软骨藻酸（DA），一种海洋毒物，和鹅膏蕈氨酸（IA），在有毒蘑菇中发现。这些兴奋性氨基酸充当谷氨酸的激动剂，是强效的神经毒素。有趣的是，这些化学物质对行为的影响完全不同。DA给药后，我们观察到记忆缺陷，只有在组的雄性小鼠在成熟。IA给药后，我们观察到在不成熟和成熟时接受治疗的雄性小鼠组的情绪行为出现偏差。相比之下，在所有雌性动物组中检测到的特征性变化很少。我们的研究结果支持的理论，化学管理的行为影响有很大不同的发展阶段和性别。总之，我们的研究结果促进了对兴奋性化学物质诱导的神经毒性的个体差异的更好理解，并为未来的风险策略和治疗提供了证据。
The structure of the brain is dramatically altered during the critical period. Physiological substances (neurotransmitters, hormones, etc.) in the body fluctuate significantly before and after sexual maturation. Therefore, the effect of chemical exposure on the central nervous system often differs depending on the developmental stage and sex. We aimed to compare the behavioural effects that emerged from the administration of chemicals to mice of different life stages (immature or mature) and different sex (male or female). We administered mice with domoic acid (DA), a marine poison, and ibotenic acid (IA), found in poisonous mushrooms. These excitatory amino acids act as agonists for glutamate and are potent neurotoxins. Interestingly, the behavioural effects of these chemicals were completely different. Following DA administration, we observed memory deficits only in groups of male mice treated at maturity. Following IA administration, we observed deviations in emotional behaviour in groups of male mice treated at both immaturity and maturity. In contrast, few characteristic changes were detected in all groups of females. Our results support the theory that the behavioural effects of chemical administration vary considerably with developmental stages and sex. In conclusion, our findings promote better understanding of individual differences in excitatory chemical-induced neurotoxicity and provide evidence for future risk strategies and treatments.