Coronary Calcium Score and Cardiovascular Risk.

Coronary Calcium Score and Cardiovascular Risk.
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DOI:
10.1016/j.jacc.2018.05.027
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发表时间:
2018-07-24
影响因子:
24
通讯作者:
Watson KE
Watson KE
中科院分区:
医学1区
文献类型:
--
作者:
Greenland P;Blaha MJ;Budoff MJ;Erbel R;Watson KE

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冠状动脉钙化(CAC)是冠状动脉粥样硬化的一个高度特异性特征。基于单中心和多中心临床和基于人群的研究以及短期和长期结局数据(长达15年随访),CAC评分已成为评估主要心血管结局风险的广泛可用、一致和可重复的方法,特别适用于无症状人群,用于计划一级预防干预措施,如他汀类药物和阿司匹林。在无症状人群中进行CAC检测在广泛的基线风险范围内具有成本效益。本综述总结了CAC的证据,包括其病理生物学,检测方式,预测作用,预测评分算法的使用,CAC进展,CAC改变患者和患者行为的临床方法的证据,CAC的新应用,CAC扫描评分的未来方向,以及新的CAC指南。
Coronary artery calcium (CAC) is a highly specific feature of coronary atherosclerosis. Based on single-center and multicenter clinical and population-based studies with short-term and long-term outcomes data (up to 15 years follow-up), CAC scoring has emerged as a widely available, consistent, and reproducible means of assessing risk of major cardiovascular outcomes, especially useful in asymptomatic people for planning primary prevention interventions such as statins and aspirin. CAC testing in asymptomatic populations is cost-effective across a broad range of baseline risk. This review summarizes evidence concerning CAC, including its pathobiology, modalities for detection, predictive role, use in prediction scoring algorithms, CAC progression, evidence that CAC changes the clinical approach to the patient and patient behavior, novel applications of CAC, future directions in scoring CAC scans, and new CAC guidelines.
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