The Euro-lupus project: epidemiology of systemic lupus erythematosus in Europe
The Euro-lupus project: epidemiology of systemic lupus erythematosus in Europe
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DOI：
10.1177/0961203309106831
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发表时间：
2009-09-01
期刊：
影响因子：
2.6
通讯作者：
Hughes, G. R. V.
中科院分区：
文献类型：
--
作者：
Cervera, R.;Khamashta, M. A.;Hughes, G. R. V.
欧洲狼疮项目提供了千年之交系统性红斑狼疮（SLE）流行病学特征的最新信息，并定义了几个临床和免疫学预后因素。欧洲狼疮队列由1000例自1991年以来前瞻性随访的SLE患者组成。在其他发现中，该项目已经表明a）疾病发作时的年龄、性别和自身抗体模式，以及其他因素，改变疾病表达并定义一些特定的SLE亚群; B）大多数SLE炎性表现在疾病的长期演变后较不常见，因此可能反映了治疗的效果以及许多患者中疾病的逐渐缓解，以及c）血栓形成事件对SLE发病率和死亡率的影响越来越明显。Lupus（2009）18，869-874.
The Euro-lupus project provides updated information on the epidemiologic characteristics of systemic lupus erythematosus (SLE) at the change of the millennium and defines several clinical and immunological prognostic factors. The Euro-lupus cohort is composed of 1000 patients with SLE who have been followed prospectively since 1991. Among other findings, this project has shown that a) the age at onset of the disease, the gender and the autoantibody pattern, among other factors, modify the disease expression and define some specific SLE subsets; b) most of the SLE inflammatory manifestations are less common after long-term evolution of the disease, thus probably reflecting the effect of therapy as well as the progressive remission of the disease in many patients and c) a more prominent role of thrombotic events is becoming evident affecting both morbidity and mortality in SLE. Lupus (2009) 18, 869-874.