Nonafluoro-tert-butoxylation of Diaryliodonium Salts
Nonafluoro-tert-butoxylation of Diaryliodonium Salts
复制标题
二芳基碘鎓盐的九氟叔丁氧基化
DOI：
10.1021/acs.orglett.9b01813
复制
发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Zhao Yanchuan
中科院分区：
文献类型：
--
作者：
Meng Huan;Wen Lixian;Xu Zhenchuang;Li Yipeng;Hao Jian;Zhao Yanchuan
提出了一种将非氟叔丁基纳入各种芳烃的高效方法。该C-O交叉偶联反应在没有过渡金属催化剂的情况下进行顺利，具有良好的官能团耐受性和可扩展性。与传统方法相比，该方法避免了使用非氟叔丁醇作为反应溶剂，并且不需要处理有害的重氮盐。制备了一系列含OC(CF3)3的19f核磁共振探针类似物，靶向各种生物相关分析物。
A highly efficient method to incorporate the nonafluoro-tert-butoxy group into various arenes is developed. This C–O cross-coupling reaction proceeds smoothly in the absence of transition-metal catalyst with good functional group tolerance and scalability. In comparison with the conventional approach, this method avoids the use of nonafluoro-tert-butyl alcohol as the reaction solvent and does not require handling of hazardous diazonium salts. A series of OC(CF3)3-containing analogues of19F NMR-based probes targeting various biologically relevant analytes are prepared.