Clinical and Microbiologic Effects of Commercially Available Dentifrice Containing Aloe Vera: A Randomized Controlled Clinical Trial
Clinical and Microbiologic Effects of Commercially Available Dentifrice Containing Aloe Vera: A Randomized Controlled Clinical Trial
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DOI：
10.1902/jop.2011.110371
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发表时间：
2012-06-01
影响因子：
4.3
通讯作者：
Naik, Savitha B.
中科院分区：
文献类型：
--
作者：
Pradeep, A. R.;Agarwal, Esha;Naik, Savitha B.
背景：民间医学中使用的某些植物作为具有抗菌和其他多种潜在作用的治疗剂的来源。这项前瞻性、随机、安慰剂和正对照临床试验旨在评估一种市售的含有芦荟的牙膏在减少牙龈炎患者的菌斑和牙龈炎症方面的临床和微生物效应。方法：选择诊断为慢性全身性牙龈炎的患者90例，随机分为3组：1组使用安慰剂牙膏；第二组，含芦荟的牙膏；第三组，含聚合物和含氟的牙膏。使用牙龈指数进行临床评估，使用改良的Quigley-Hein指数评估菌斑，并在基线、6周、12周和24周评估微生物计数。还通过问卷进行了主观评价。结果：与安慰剂牙膏相比，含有芦荟的牙膏在牙龈和菌斑指数评分以及微生物计数方面均有显著改善。这些改善与含有三氯生的牙膏所取得的效果相当。结论：芦荟牙膏可能是一种有效的化学牙菌斑控制剂，可改善牙菌斑和牙龈状况。中华牙周病杂志（英文版）；2009;33(3):391 - 391。
Background: Certain plants used in folk medicine serve as a source of therapeutic agents that have antimicrobial and other multipotential effects. This prospective, randomized, placebo, and positively controlled clinical trial was designed to evaluate the clinical and microbiologic effects of a commercially available dentifrice containing aloe vera on the reduction of plaque and gingival inflammation in patients with gingivitis.Methods: Ninety patients diagnosed with chronic generalized gingivitis were selected and randomly divided into three groups: group 1, placebo toothpaste; group 2, toothpaste containing aloe vera; and group 3, toothpaste with polymer and fluoride containing triclosan. Clinical evaluation was undertaken using a gingival index, plaque was assessed using a modification of the Quigley-Hein index, and microbiologic counts were assessed at baseline, 6 weeks, 12 weeks, and 24 weeks. A subjective evaluation was also undertaken by questionnaire.Results: Toothpaste containing aloe vera showed significant improvement in gingival and plaque index scores as well as microbiologic counts compared with placebo dentifrice. These improvements were comparable to those achieved with toothpaste containing triclosan.Conclusion: Toothpaste containing aloe vera may be a useful herbal formulation for chemical plaque control agents and improvement in plaque and gingival status. J Periodontol 2012;83:797-804.