Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing.
Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing.
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DOI：
10.1186/s13041-017-0291-1
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发表时间：
2017-04-06
期刊：
影响因子：
3.6
通讯作者：
Emeson RB
中科院分区：
文献类型：
--
作者：
O'Neil RT;Wang X;Morabito MV;Emeson RB
A-to-IRNA编辑是通过修饰编码对神经元信号传导重要的几种蛋白质的转录物来在大脑中产生分子多样性的重要过程。我们研究了从成年人和恒河猴获得的脑组织中多种底物转录物（5 HT 2C、MGLUR 4、CADPS、GLUR 2、GLUR 4和GABRA 3）的编辑程度之间的关系。从这些研究中出现的几种模式揭示了灵长类物种之间的编辑保守性。此外，人类群体的变异性使我们能够对不同编辑位点甚至不同大脑区域的编辑协同调节做出新的推断。本文的在线版本（doi：10.1186/s13041-017-0291-1）包含补充材料，可供授权用户使用。
A-to-I RNA editing is an important process for generating molecular diversity in the brain through modification of transcripts encoding several proteins important for neuronal signaling. We investigated the relationships between the extent of editing at multiple substrate transcripts (5HT2C, MGLUR4, CADPS, GLUR2, GLUR4, and GABRA3) in brain tissue obtained from adult humans and rhesus macaques. Several patterns emerged from these studies revealing conservation of editing across primate species. Additionally, variability in the human population allows us to make novel inferences about the co-regulation of editing at different editing sites and even across different brain regions. The online version of this article (doi:10.1186/s13041-017-0291-1) contains supplementary material, which is available to authorized users.