Malaria: Thermoregulation in a parasite's life cycle
Malaria: Thermoregulation in a parasite's life cycle
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DOI：
10.1038/418742a
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发表时间：
2002-08-15
期刊：
影响因子：
64.8
通讯作者：
McCutchan, TF
中科院分区：
文献类型：
--
作者：
Fang, J;McCutchan, TF
恶性疟原虫的生命周期经历了三个发育阶段(分裂生殖、配子生殖和孢子生殖)，每个阶段都呈现出不同的环境限制，必须通过寄生虫的适应性反应来满足。在这里，我们表明温度调节，其中选择的RNA的转录在较低的温度下上调，是发生在OFP传递过程中的发育转变的关键。恶性疟原虫从人传给蚊子。我们的发现为疟疾寄生虫如何感知和对其环境做出反应提供了新的见解。
The life cycle of the malaria parasitePlasmodium falciparumgoes through three developmental stages (schizogony, gametogony and sporogony), each of which presents different environmental constraints that must be met by an adaptive response in the parasite. Here we show that thermoregulation, in which the transcription of select RNAs is upregulated at cooler temperatures, is crucial to the developmental transition that occurs during the transmission ofP. falciparumfrom human to mosquito. Our findings offer new insight into how the malaria parasite senses and reacts to its environment.