PROTEOLYTIC REMODELING OF EXTRACELLULAR-MATRIX
PROTEOLYTIC REMODELING OF EXTRACELLULAR-MATRIX
复制标题
DOI：
10.1016/0955-0674(95)80116-2
复制
发表时间：
1995-10-01
影响因子：
7.5
通讯作者：
BIRKEDALHANSEN, H
中科院分区：
文献类型：
--
作者：
BIRKEDALHANSEN, H
基质金属蛋白酶及其天然抑制物是影响环境变化的基本细胞工具箱的成分。这些酶通过直接裂解细胞外基质的结构大分子，使细胞能够改变它们与环境的关系。此外，越来越多的证据表明，它们还通过催化失活的基质金属蛋白酶和细胞因子前体的处理，在基质重塑中发挥重要的调节作用。
Matrix metalloproteinases and their natural inhibitors are ingredients of a fundamental cellular toolbox for effecting environmental change. These enzymes enable cells to alter their relationship to the environment by directly cleaving structural macromolecules of the extracellular matrix. In addition, evidence is emerging that they also play an important regulatory role in matrix remodeling by catalyzing the processing of inactive matrix metalloproteinase and cytokine precursors.